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Protein Page:
ALPP (human)

ALPP There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]
Protein type: Cell surface; Cofactor and Vitamin Metabolism - folate biosynthesis; EC; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: cell surface
Molecular Function: alkaline phosphatase activity; magnesium ion binding; protein binding; zinc ion binding
Reference #:  P05187 (UniProtKB)
Alt. Names/Synonyms: Alkaline phosphatase Regan isozyme; alkaline phosphatase, placental (Regan isozyme); Alkaline phosphatase, placental type; alkaline phosphomonoesterase; ALP; ALPP; FLJ61142; glycerophosphatase; PALP; Placental alkaline phosphatase 1; PLAP; PLAP-1; PPB1
Gene Symbols: ALPP
Molecular weight: 57,954 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.
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