a proto-oncogenic transcription factor of the bZIP family. Dimerizes with proteins of the JUN family, thereby forming the transcription factor complex AP-1. FOS proteins function as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of FOS has also been associated with apoptotic cell death. Expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Molecular Function: chromatin binding; protein binding; protein heterodimerization activity; transcription factor activity; transcription factor binding
Biological Process: aging; cellular response to extracellular stimulus; cellular response to hormone stimulus; conditioned taste aversion; DNA methylation; female pregnancy; inflammatory response; nervous system development; positive regulation of osteoclast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription factor activity; regulation of transcription from RNA polymerase II promoter; response to cAMP; response to cold; response to corticosterone stimulus; response to cytokine stimulus; response to drug; response to gravity; response to light stimulus; response to lipopolysaccharide; response to progesterone stimulus; response to toxin; sleep; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.