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Protein Page:
VCAM1 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VCAM1 Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p32-p31
Cellular Component: apical part of cell; cell surface; early endosome; endoplasmic reticulum; external side of plasma membrane; extracellular space; filopodium; Golgi apparatus; integral to membrane; microvillus; plasma membrane; podosome; sarcolemma
Molecular Function: amine oxidase activity; cell adhesion molecule binding; integrin binding
Biological Process: acute inflammatory response; aging; amine metabolic process; B cell differentiation; cell adhesion; cell-matrix adhesion; chronic inflammatory response; cytokine and chemokine mediated signaling pathway; extracellular matrix organization and biogenesis; heart development; heterophilic cell adhesion; leukocyte adhesion; leukocyte tethering or rolling; membrane to membrane docking; positive regulation of T cell proliferation; regulation of immune response; response to ethanol; response to hypoxia; response to ionizing radiation; response to lipopolysaccharide; response to nicotine; response to nutrient; response to zinc ion; viral reproduction
Reference #:  P19320 (UniProtKB)
Alt. Names/Synonyms: CD106; CD106 antigen; DKFZp779G2333; INCAM-100; L1CAM; MGC99561; V-CAM 1; vascular cell adhesion molecule 1; Vascular cell adhesion protein 1; VCAM-1; VCAM1
Gene Symbols: VCAM1
Molecular weight: 81,276 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VCAM1

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 7 E166 MKSQEFLEDADRKSL
0 1 R170 EFLEDADRKSLETKS
0 1 F494 LHIDDMEFEPKQRQS
0 1 Y653‑p LKSIDGAyTIRKAQL
0 3 Y703‑p SPELLVLyFAssLII
0 1 S706‑p LLVLyFAssLIIPAI
0 1 S707‑p LVLyFAssLIIPAIG
0 2 Y718‑p PAIGMIIyFARKANM
0 1 K736 YSLVEAQKSKV____
  mouse

 
S166‑p MNRQEFSsEEMtKSL
T170‑p EFSsEEMtKSLETKS
S494‑p LHSGEMEsEPKQRQS
Y653 LKSVDGSYTIRQAQL
Y703 SPELLALYCASSLVI
S706 LLALYCASSLVIPAI
S707 LALYCASSLVIPAIG
Y718 PAIGMIVYFARKANM
K736‑ub YSLVEAQkSKV____
  rat

 
D166 MKKQDFVDEMAKKSL
K170 DFVDEMAKKSLETKS
S494 LHSSQMESEPKQRQS
Y653 LKSVNGSYTIRKAQL
Y703 SPELLALYFASSLVI
S706 LLALYFASSLVIPAI
S707 LALYFASSLVIPAIG
Y718 PAIGMIIYFARKANM
K736 YSLVEAQKSKV____
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