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Protein Page:
FGFR4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGFR4 a tyrosine-kinase receptor that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of the MAP kinase and AKT signaling pathways. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling. Two isoforms of the human protein are formed by alternative splicing. This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; FGFR family
Chromosomal Location of Human Ortholog: 5q35.2
Cellular Component: cytoplasm; endoplasmic reticulum; endosome; extracellular region; Golgi apparatus; integral to plasma membrane; intercellular junction; nucleoplasm; plasma membrane; transport vesicle
Molecular Function: 1-phosphatidylinositol-3-kinase activity; ATP binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; heparin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: cell migration; fibroblast growth factor receptor signaling pathway; glucose homeostasis; MAPKKK cascade; peptidyl-tyrosine phosphorylation; phosphate ion homeostasis; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of GTPase activity; positive regulation of proteolysis; protein amino acid autophosphorylation; regulation of lipid metabolic process; regulation of phosphoinositide 3-kinase cascade
Reference #:  P22455 (UniProtKB)
Alt. Names/Synonyms: CD334; FGFR-4; FGFR4; Fibroblast growth factor receptor 4; JTK2; MGC20292; TKF; tyrosine kinase related to fibroblast growth factor receptor
Gene Symbols: FGFR4
Molecular weight: 87,954 Da
Basal Isoelectric point: 6.36  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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FGFR4

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 T167‑p HAVPAGNtVKFRCPA
0 1 S232‑p LVENAVGsIRYNYLL
0 1 N236 AVGsIRYNYLLDVLE
0 1 Y237 VGsIRYNYLLDVLER
0 1 T368‑p AAPEARYtDIILYAS
1 0 Y390‑p LLLLAGLyRGQALHG
0 1 K408 RPPATVQKLsRFPLA
0 1 S410‑p PATVQKLsRFPLARQ
0 10 S419‑p FPLARQFsLEsGSSG
0 1 S422‑p ARQFsLEsGSSGKSS
0 1 K427 LEsGSSGKSSSSLVR
0 13 S439‑p LVRGVRLsssGPALL
0 12 S440‑p VRGVRLsssGPALLA
0 3 S441‑p RGVRLsssGPALLAG
0 2 K471 RDRLVLGKPLGEGCF
0 1 S519‑p KDLADLVsEMEVMKL
0 9 S573‑p RPPGPDLsPDGPRSS
0 1 K627‑ub VTEDNVMkIADFGLA
0 56 Y642‑p RGVHHIDyyKKTSNG
0 34 Y643‑p GVHHIDyyKKTSNGR
1 9 Y754‑p LLAVSEEyLDLRLTF
  FGFR4 iso2  
- gap
T167 HAVPAGNTVKFRCPA
S232 LVENAVGSIRYNYLL
N236 AVGSIRYNYLLDVLE
Y237 VGSIRYNYLLDVLER
- gap
- gap
- gap
- gap
S379 KSPTLQFSLESGSSG
S382 TLQFSLESGSSGKSS
K387 LESGSSGKSSSSLVR
S399 LVRGVRLSSSGPALL
S400 VRGVRLSSSGPALLA
S401 RGVRLSSSGPALLAG
K431 RDRLVLGKPLGEGCF
S479 KDLADLVSEMEVMKL
S533 RPPGPDLSPDGPRSS
K587 VTEDNVMKIADFGLA
Y602 RGVHHIDYYKKTSNG
Y603 GVHHIDYYKKTSNGR
Y714 LLAVSEEYLDLRLTF
  FGFR4 iso3  
K223‑ub IGTVTPSkVSRSPRT
T282 HAVPAGNTVKFRCPA
S347 LVENAVGSIRYNYLL
N351 AVGSIRYNYLLDVLE
Y352 VGSIRYNYLLDVLER
T600 AAPEARYTDIILYAS
Y622 LLLLARLYRGQALHG
K640 RPPATVQKLSRFPLA
S642 PATVQKLSRFPLARQ
S651‑p FPLARQFsLESGSSG
S654 ARQFsLESGSSGKSS
K659 LESGSSGKSSSSLVR
S671 LVRGVRLSSSGPALL
S672 VRGVRLSSSGPALLA
S673 RGVRLSSSGPALLAG
K703 RDRLVLGKPLGEGCF
S751 KDLADLVSEMEVMKL
S805 RPPGPDLSPDGPRSS
K859 VTEDNVMKIADFGLA
Y874 RGVHHIDYYKKTSNG
Y875 GVHHIDYYKKTSNGR
Y986 LLAVSEEYLDLRLTF
  mouse

 
- gap
T164 HAVPAGNTVKFRCPA
S229 LVENSLGSIRYsyLL
S233‑p SLGSIRYsyLLDVLE
Y234‑p LGSIRYsyLLDVLER
T365 ATPEARYTDIILYVS
Y387 LLLLAGVYHRQVIRG
K405‑ub RQPVTIQkLSRFPLA
S407 PVTIQkLSRFPLARQ
S416 FPLARQFSLESRSSG
S419 ARQFSLESRSSGkSS
K424‑ub LESRSSGkSSLSLVR
S436 LVRGVRLSSSGPPLL
S437 VRGVRLSSSGPPLLT
S438 RGVRLSSSGPPLLTG
K468‑ub RDRLVLGkPLGEGCF
S516 KDLADLVSEMEVMKL
S570‑p RPPGPDLsPDGPRSS
K624 VTEDDVMKIADFGLA
Y639‑p RGVHHIDyyKKTSNG
Y640‑p GVHHIDyyKKTSNGR
Y751‑p LLAVSEEyLDLRLTF
  rat

 
- gap
T163 HAVPAGNTVKFRCPA
S228 LVENSLGSIRYSYLL
S232 SLGSIRYSYLLDVLE
Y233 LGSIRYSYLLDVLER
T366 ATSEARYTDIILYVS
Y388 LLLLAGVYHRQAIHG
K406 RQPVTVQKLSRFPLA
S408 PVTVQKLSRFPLARQ
S417‑p FPLARQFsLESRSSG
S420 ARQFsLESRSSGKSS
K425 LESRSSGKSSLSLVR
S437 LVRGVRLSSSGPPLL
S438 VRGVRLSSSGPPLLT
S439 RGVRLSSSGPPLLTG
K469 RDRLVLGKPLGEGCF
S517 KDLADLISEMEMMKL
S571 RPPGPDLSPDGPRSS
K625 VTEDDVMKIADFGLA
Y640 RGVHHIDYYKKTSNG
Y641 GVHHIDYYKKTSNGR
Y752 LLAVSEEYLDLRLTF
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