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Protein Page:
FGFR2 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGFR2 a receptor tyrosine kinase of the highly-conserved FGFR family that binds fibroblast growth factor (FGF). Mutations are associated with many craniosynostotic syndromes and bone malformations. Mutations cause syndromes with defects in facial and limb development, including Crouzon syndrome, Beare-Stevenson cutis gyrata syndrome, Pfeiffer syndrome, Apert syndrome, and Jackson-Weiss syndrome. Somatic mutations seen in gastric cancer. Amplified in gastric, breast and some B cell cancers, but deleted in glioblastoma Twenty splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; TK group; FGFR family
Chromosomal Location of Human Ortholog: 10q26
Cellular Component: cell cortex; cell surface; cytoplasm; cytoplasmic membrane-bound vesicle; excitatory synapse; extracellular matrix; extracellular region; Golgi apparatus; integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; membrane; nucleoplasm; nucleus; plasma membrane
Molecular Function: ATP binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; heparin binding; protein binding; protein homodimerization activity; protein-tyrosine kinase activity
Biological Process: activation of MAPKK activity; alveolus development; angiogenesis; apoptosis; axon guidance; axonogenesis; bone mineralization; branching morphogenesis of a nerve; cell fate commitment; cell-cell signaling; embryonic cranial skeleton morphogenesis; embryonic digestive tract morphogenesis; embryonic organ development; embryonic organ morphogenesis; embryonic pattern specification; epidermal growth factor receptor signaling pathway; epidermis morphogenesis; epithelial cell differentiation; epithelial to mesenchymal transition; fibroblast growth factor receptor signaling pathway; gland morphogenesis; gut development; hair follicle morphogenesis; in utero embryonic development; innate immune response; inner ear morphogenesis; insulin receptor signaling pathway; lacrimal gland development; limb bud formation; lung development; MAPKKK cascade; mesenchymal cell differentiation; mesodermal cell differentiation; midbrain development; morphogenesis of embryonic epithelium; multicellular organism growth; negative regulation of epithelial cell proliferation; negative regulation of mitosis; negative regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; neuroblast division in the ventricular zone; neuromuscular junction development; odontogenesis; orbitofrontal cortex development; organ growth; organ morphogenesis; otic vesicle formation; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of MAPKKK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Wnt receptor signaling pathway; post-embryonic development; protein amino acid autophosphorylation; pyramidal neuron development; Ras protein signal transduction; regulation of cell fate commitment; regulation of fibroblast growth factor receptor signaling pathway; regulation of multicellular organism growth; regulation of osteoblast differentiation; regulation of osteoblast proliferation; regulation of smooth muscle cell differentiation; regulation of smoothened signaling pathway; reproductive structure development; skeletal morphogenesis; small GTPase mediated signal transduction; synaptic vesicle transport; ureteric bud development; vascular endothelial growth factor receptor signaling pathway; ventricular cardiac muscle morphogenesis
Disease: Antley-bixler Syndrome Without Genital Anomalies Or Disordered Steroidogenesis; Apert Syndrome; Beare-stevenson Cutis Gyrata Syndrome; Bent Bone Dysplasia Syndrome; Crouzon Syndrome; Gastric Cancer; Jackson-weiss Syndrome; Lacrimoauriculodentodigital Syndrome; Pfeiffer Syndrome; Saethre-chotzen Syndrome; Scaphocephaly, Maxillary Retrusion, And Mental Retardation
Reference #:  P21802 (UniProtKB)
Alt. Names/Synonyms: bacteria-expressed kinase; BEK; BEK fibroblast growth factor receptor; BFR-1; CD332; CEK3; CFD1; ECT1; FGF receptor; FGFR-2; FGFR2; Fibroblast growth factor receptor 2; FLJ98662; JWS; K-sam; Keratinocyte growth factor receptor; KGFR; KSAM; protein tyrosine kinase, receptor like 14; soluble FGFR4 variant 4; TK14; TK25
Gene Symbols: FGFR2
Molecular weight: 92,025 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FGFR2

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S782‑p
cell growth, altered: Y769‑p, S782‑p
enzymatic activity, induced: Y769‑p
molecular association, regulation: Y769‑p, S782‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 S347‑p YTCLAGNsIGISFHS
0 1 S437‑p VSAESSSsMNsNtPL
0 1 S440‑p ESSSsMNsNtPLVRI
0 1 T442‑p SSsMNsNtPLVRItt
0 11 T448‑p NtPLVRIttRLsstA
0 6 T449‑p tPLVRIttRLsstAD
0 17 S452‑p VRIttRLsstADtPM
0 15 S453‑p RIttRLsstADtPML
0 15 T454‑p IttRLsstADtPMLA
0 2 T457‑p RLsstADtPMLAGVS
0 5 Y466‑p MLAGVSEyELPEDPK
0 1 K539‑ac VSEMEMMkMIGKHKN
0 13 Y586‑p RRPPGMEysyDINRV
0 3 S587‑p RPPGMEysyDINRVP
0 8 Y588‑p PPGMEysyDINRVPE
0 1 S605 MTFKDLVSCTyQLAR
0 6 Y608‑p KDLVSCTyQLARGME
0 2 Y616‑p QLARGMEyLASQKCI
0 72 Y656‑p RDINNIDyyKKTTNG
0 41 Y657‑p DINNIDyyKKTTNGR
0 2 Y733‑p ANCTNELyMMMRDCW
0 2 K751‑ub PSQRPTFkQLVEDLD
5 0 Y769‑p TLTTNEEyLDLSQPL
0 1 S780‑p SQPLEQYsPsYPDTR
2 0 S782‑p PLEQYsPsYPDTRss
0 1 S788‑p PsYPDTRssCssGDD
0 1 S789‑p sYPDTRssCssGDDS
0 1 S791‑p PDTRssCssGDDSVF
0 1 S792‑p DTRssCssGDDSVFS
0 1 Y805‑p FSPDPMPyEPCLPQy
0 1 Y812‑p yEPCLPQyPHINGSV
  FGFR2 iso3  
S343 GEYICKVSNYIGQAN
Y345 YICKVSNYIGQANQS
S438 VSAESSSSMNSNTPL
S441 ESSSSMNSNTPLVRI
T443 SSSMNSNTPLVRITT
T449 NTPLVRITTRLSSTA
T450 TPLVRITTRLSSTAD
S453 VRITTRLSSTADTPM
S454 RITTRLSSTADTPML
T455 ITTRLSSTADTPMLA
T458 RLSSTADTPMLAGVS
Y467 MLAGVSEYELPEDPK
K540 VSEMEMMKMIGKHKN
Y587 RRPPGMEYSYDINRV
S588 RPPGMEYSYDINRVP
Y589 PPGMEYSYDINRVPE
S606 MTFKDLVSCTYQLAR
Y609 KDLVSCTYQLARGME
Y617 QLARGMEYLASQKCI
Y657 RDINNIDYYKKTTNG
Y658 DINNIDYYKKTTNGR
Y734 ANCTNELYMMMRDCW
K752 PSQRPTFKQLVEDLD
Y770 TLTTNEEYLDLSQPL
S781 SQPLEQYSPSYPDTR
S783 PLEQYSPSYPDTRSS
S789 PSYPDTRSSCSSGDD
S790 SYPDTRSSCSSGDDS
S792 PDTRSSCSSGDDSVF
S793 DTRSSCSSGDDSVFS
Y806 FSPDPMPYEPCLPQY
Y813 YEPCLPQYPHINGSV
  mouse

► Hide Isoforms
 
- gap
S347 YTCLAGNSIGISFHS
S437 VSAESSSSMNSNTPL
S440 ESSSSMNSNTPLVRI
T442 SSSMNSNTPLVRItT
T448‑p NTPLVRItTRLSSTA
T449 TPLVRItTRLSSTAD
S452 VRItTRLSSTADTPM
S453 RItTRLSSTADTPML
T454 ItTRLSSTADTPMLA
T457 RLSSTADTPMLAGVS
Y466 MLAGVSEYELPEDPK
K539 VSEMEMMKMIGKHKN
Y586 RRPPGMEYSYDINRV
S587 RPPGMEYSYDINRVP
Y588 PPGMEYSYDINRVPE
S605 MTFKDLVSCTYQLAR
Y608 KDLVSCTYQLARGME
Y616 QLARGMEYLASQKCI
Y656‑p RDINNIDyyKKTTNG
Y657‑p DINNIDyyKKTTNGR
Y733 TNCTNELYMMMRDCW
K751 PSQRPTFKQLVEDLD
Y769‑p TLTTNEEyLDLTQPL
S780 TQPLEQYSPSYPDTS
S782 PLEQYSPSYPDTSSS
S788 PSYPDTSSSCSSGDD
S789 SYPDTSSSCSSGDDS
S791 PDTSSSCSSGDDSVF
S792 DTSSSCSSGDDSVFS
Y805 FSPDPMPYEPCLPQY
Y812 YEPCLPQYPHINGSV
  FGFR2 iso2  
S228‑p GEYICKVsNYIGQAN
Y230 YICKVsNYIGQANQS
S323 VSAESSSSMNSNTPL
S326 ESSSSMNSNTPLVRI
T328 SSSMNSNTPLVRITT
T334 NTPLVRITTRLSSTA
T335 TPLVRITTRLSSTAD
S338 VRITTRLSSTADTPM
S339 RITTRLSSTADTPML
T340 ITTRLSSTADTPMLA
T343 RLSSTADTPMLAGVS
Y352 MLAGVSEYELPEDPK
K425 VSEMEMMKMIGKHKN
Y472 RRPPGMEYSYDINRV
S473 RPPGMEYSYDINRVP
Y474 PPGMEYSYDINRVPE
S491 MTFKDLVSCTYQLAR
Y494 KDLVSCTYQLARGME
Y502 QLARGMEYLASQKCI
Y542 RDINNIDYYKKTTNG
Y543 DINNIDYYKKTTNGR
Y619 TNCTNELYMMMRDCW
K637 PSQRPTFKQLVEDLD
Y655 TLTTNEEYLDLTQPL
S666 TQPLEQYSPSYPDTS
S668 PLEQYSPSYPDTSSS
S674 PSYPDTSSSCSSGDD
S675 SYPDTSSSCSSGDDS
S677 PDTSSSCSSGDDSVF
S678 DTSSSCSSGDDSVFS
Y691 FSPDPMPYEPCLPQY
Y698 YEPCLPQYPHINGSV
  rat

 
S362 GEYICKVSNYIGQAN
Y364 YICKVSNYIGQANQS
S457 VSAESSSSMNSNTPL
S460 ESSSSMNSNTPLVRI
T462 SSSMNSNTPLVRITT
T468 NTPLVRITTRLSSTA
T469 TPLVRITTRLSSTAD
S472 VRITTRLSSTADTPM
S473 RITTRLSSTADTPML
T474 ITTRLSSTADTPMLA
T477 RLSSTADTPMLAGVS
Y486 MLAGVSEYELPEDPK
K559 VSEMEMMKMIGKHKN
Y606‑p RRPPGMEySYDINRV
S607 RPPGMEySYDINRVP
Y608 PPGMEySYDINRVPE
S625‑p MTFKDLVsCTYQLAR
Y628 KDLVsCTYQLARGME
Y636 QLARGMEYLASQKCI
Y676‑p RDINNIDyyKKTTNG
Y677‑p DINNIDyyKKTTNGR
Y753 TNCTNELYMMMRDCW
K771 PSQRPTFKQLVEDLD
Y789‑p TLTTNEEyLDLTQPL
S800 TQPLEQYSPSYPDTR
S802 PLEQYSPSYPDTRSS
S808 PSYPDTRSSCSSGDD
S809 SYPDTRSSCSSGDDS
S811 PDTRSSCSSGDDSVF
S812 DTRSSCSSGDDSVFS
Y825 FSPDPMPYDPCLPQY
Y832 YDPCLPQYPHINGSV
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