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Protein Page:
ARP2 (human)

ARP2 Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Belongs to the actin family. ARP2 subfamily. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2p14
Cellular Component: actin cytoskeleton; Arp2/3 protein complex; cytoplasm; cytosol; focal adhesion; membrane
Molecular Function: actin filament binding; structural constituent of cytoskeleton
Biological Process: cell motility; cilium biogenesis; ephrin receptor signaling pathway
Reference #:  P61160 (UniProtKB)
Alt. Names/Synonyms: Actin-like protein 2; Actin-related protein 2; ACTR2; ARP2; ARP2 actin-related protein 2 homolog (yeast)
Gene Symbols: ACTR2
Molecular weight: 44,761 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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