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Protein Page:
TSPO (human)

Overview
TSPO Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells. Belongs to the TspO/BZRP family. Interacts with BZRAP1. May interact with STAR. Interacts with MOST-1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Receptor, misc.; Mitochondrial; Membrane protein, integral; Apoptosis
Chromosomal Location of Human Ortholog: 22q13.31
Cellular Component: cytoplasm; integral to membrane; intracellular membrane-bound organelle; mitochondrial outer membrane; mitochondrion; nuclear membrane
Molecular Function: androgen binding; benzodiazepine receptor activity; cholesterol binding; protein binding
Biological Process: adrenal gland development; aging; anion transport; apoptosis; axon regeneration in the peripheral nervous system; behavioral response to pain; cell proliferation; chloride transport; glial cell migration; heme biosynthetic process; lipid transport; negative regulation of nitric oxide biosynthetic process; negative regulation of protein ubiquitination; negative regulation of tumor necrosis factor production; positive regulation of apoptosis; positive regulation of calcium ion transport; positive regulation of mitochondrial depolarization; protein targeting to mitochondrion; regulation of cholesterol transport; regulation of steroid biosynthetic process; response to drug; response to manganese ion; response to progesterone stimulus; response to testosterone stimulus; response to vitamin B1; steroid biosynthetic process; steroid metabolic process; synaptic transmission
Reference #:  P30536 (UniProtKB)
Alt. Names/Synonyms: benzodiazepine peripheral binding site; BZRP; DBI; IBP; MBR; mDRC; Mitochondrial benzodiazepine receptor; PBR; peripheral benzodiazepine receptor; Peripheral-type benzodiazepine receptor; pk18; PKBS; PTBR; RP3-526I14.4; Translocator protein; translocator protein (18kDa); TSPO; TSPOA
Gene Symbols: TSPO
Molecular weight: 18,828 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TSPO

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 R165 NHGWRGGRRLPE___
  TSPO iso2  
- gap
  mouse

 
S165‑p NSGRRGGsRLPE___
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