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Protein Page:
ORC1L (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ORC1L Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Belongs to the ORC1 family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; DNA-binding
Chromosomal Location of Human Ortholog: 1p32
Cellular Component: cytoplasm; cytosol; nuclear chromosome, telomeric region; nuclear origin of replication recognition complex; nucleolus; nucleoplasm; nucleus; origin recognition complex; plasma membrane
Molecular Function: ATP binding; chromatin binding; DNA binding; protein binding
Biological Process: DNA replication; DNA replication initiation; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; positive regulation of smooth muscle cell proliferation
Disease: Meier-gorlin Syndrome 1
Reference #:  Q13415 (UniProtKB)
Gene Symbols: ORC1
Molecular weight: 97,350 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ORC1L

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T6 __MAHYPTRLKTRKT
0 1 K99‑ub FCEVPACkRHLLGRK
0 1 S182‑p ELNKPQEsAAKCQKP
0 1 S194‑p QKPVRAKsKsAEsPs
0 3 S196‑p PVRAKsKsAEsPsWt
0 9 S199‑p AKsKsAEsPsWtPAE
0 1 S201‑p sKsAEsPsWtPAEHV
0 8 T203‑p sAEsPsWtPAEHVAK
0 1 S217‑p KRIESRHsASKsRQt
0 3 S221‑p SRHsASKsRQtPTHP
0 8 T224‑p sASKsRQtPTHPLtP
0 15 T230‑p QtPTHPLtPRARKRL
0 1 S252 PQMSQQTSCAsLDsP
0 3 S255‑p SQQTSCAsLDsPGRI
1 5 S258‑p TSCAsLDsPGRIKRK
0 2 S269‑p IKRKVAFsEITsPsK
1 10 S273‑p VAFsEITsPsKRSQP
0 1 S275‑p FsEITsPsKRSQPDK
0 1 T285‑p SQPDKLQtLsPALKA
0 11 S287‑p PDKLQtLsPALKAPE
0 10 S311‑p TEDDKKAsPEHRIIL
0 1 K326‑ac RTRIAASkTIDIREE
0 1 K326 RTRIAASKTIDIREE
0 1 I328 RIAASkTIDIREERT
0 13 T337‑p IREERTLtPIsGGQR
0 4 S340‑p ERTLtPIsGGQRSSV
0 1 S350‑p QRSSVVPsVILKPEN
0 1 K354 VVPsVILKPENIKKR
0 1 K364‑ac NIKKRDAkEAKAQNE
0 2 T373‑p AKAQNEAtstPHRIR
0 1 S374‑p KAQNEAtstPHRIRR
1 7 T375‑p AQNEAtstPHRIRRK
0 4 S383‑p PHRIRRKssVLtMNR
0 6 S384‑p HRIRRKssVLtMNRI
0 2 T387‑p RRKssVLtMNRIRQQ
0 2 S417‑p ILPAAEIsDsssDEE
0 1 S419‑p PAAEIsDsssDEEEA
0 2 S420‑p AAEIsDsssDEEEAs
0 2 S421‑p AEIsDsssDEEEAsT
0 1 S427‑p ssDEEEAsTPPLPRR
0 1 S449‑p NLRSSLKssLHtLtK
0 1 S450‑p LRSSLKssLHtLtKV
0 1 T453‑p SLKssLHtLtKVPKK
0 1 T455‑p KssLHtLtKVPKKsL
0 1 S461‑p LtKVPKKsLKPRTPR
0 1 S476‑p CAAPQIRsRsLAAQE
0 5 S478‑p APQIRsRsLAAQEPA
0 1 K603‑ub HAAELLAkQFCTRGs
0 1 S610‑p kQFCTRGsPQETTVL
0 5 S850‑p LRVRLNVsQDDVLYA
0 1 K859‑ub DDVLYALkDE_____
  mouse

► Hide Isoforms
 
T6‑p __MPSYLtRQKTRQT
K98 FLEIPVSKRHLLGRS
S181 ALREQEDSPEWQKPL
I192 QKPLKAKIKNVKSPA
N194 PLKAKIKNVKSPARN
S197 AKIKNVKSPARNTTE
A199 IKNVKSPARNTTEQE
N201 NVKSPARNTTEQEVK
S215 KGIKSNHSTSKFHQT
F219 SNHSTSKFHQTPANI
T222 STSKFHQTPANIVIP
I228 QTPANIVIPNAKKSL
S255‑p TRWSKKSsCDsLDYQ
S258‑p SKKSsCDsLDYQKTS
Y261 SsCDsLDYQKTSKRR
S272 SKRRAAFSETTsPPK
S276‑p AAFSETTsPPKKPNK
P278 FSETTsPPKKPNKPR
K288 PNKPREIKPSSALET
S290 KPREIKPSSALETRV
C306 NGQTQPFCAKSSVVL
T321 RARNPAMTTtKLGVD
T321‑p RARNPAMtTtKLGVD
T323‑p RNPAMtTtKLGVDNT
S332‑p LGVDNTLsPIRNGLR
R335 DNTLsPIRNGLRSSV
S345 LRSSVVPSGGLtPVY
T349‑p VVPSGGLtPVYIRRK
K358 VYIRRKAKEQETHKE
R368 ETHKEPIRTSRVHRK
T369 THKEPIRTSRVHRKs
S370 HKEPIRTSRVHRKss
S376‑p TSRVHRKssLLtLKR
S377‑p SRVHRKssLLtLKRI
T380‑p HRKssLLtLKRIRQQ
- gap
S406 EEEESVDSESEEEDE
E407 EEESVDSESEEEDEF
S408 EESVDSESEEEDEFI
F414 ESEEEDEFISSLPTR
- gap
- gap
T432 GQSRTRQTPSKSPQK
S434 SRTRQTPSKSPQKNP
N440 PSKSPQKNPKPRTPH
D455 RATPQIRDRNLAVQE
N457 TPQIRDRNLAVQEPA
K582 HAAELLAKQFCGQGS
S589 KQFCGQGSQKETTVL
S829 LRVRLNVSQNDVLFA
K838 NDVLFALKEE_____
  ORC1L var1  
T6 __MPSYLTRQKTRQT
K98 FLEIPVSKRHLLGRS
S181 ALREQEDSPEWQKPL
I192 QKPLKAKIKNVKSPA
N194 PLKAKIKNVKSPARN
S197 AKIKNVKSPARNTTE
A199 IKNVKSPARNTTEQE
N201 NVKSPARNTTEQEVK
S215 KGIKSNHSTSKFHQT
F219 SNHSTSKFHQTPANI
T222 STSKFHQTPANIVIP
I228 QTPANIVIPsAKKSL
S255 TRWSKKSSCDSLDYQ
S258 SKKSSCDSLDYQKTS
Y261 SSCDSLDYQKTSKRR
S272 SKRRAAFSETTSPPK
S276 AAFSETTSPPKKPNK
P278 FSETTSPPKKPNKPR
K288 PNKPREIKPSSALET
S290 KPREIKPSSALETRV
C306 NGQTQPFCAKSSVVL
T321 RARNPAMTTTKLGVD
T321 RARNPAMTTTKLGVD
T323 RNPAMTTTKLGVDNT
S332 LGVDNTLSPIRNGLR
R335 DNTLSPIRNGLRSSV
S345 LRSSVVPSGGLTPVY
T349 VVPSGGLTPVYIRRK
K358 VYIRRKAKEQETHKE
R368 ETHKEPIRTSRVHRK
T369 THKEPIRTSRVHRKS
S370 HKEPIRTSRVHRKSS
S376 TSRVHRKSSLLTLKR
S377 SRVHRKSSLLTLKRI
T380 HRKSSLLTLKRIRQQ
- gap
S406 EEEESVDSESEEEDE
E407 EEESVDSESEEEDEF
S408 EESVDSESEEEDEFI
F414 ESEEEDEFISSLPTR
- gap
- gap
T432 GQSRTRQTPSKSPQK
S434 SRTRQTPSKSPQKNP
N440 PSKSPQKNPKPRTPH
D455 RATPQIRDRNLAVQE
N457 TPQIRDRNLAVQEPA
K582 HAAELLAKQFCGQGS
S589 KQFCGQGSQKETTVL
S829 LRVRLNVSQNDVLFA
K838 NDVLFALKEE_____
  rat

 
T6 __MPSYVTRQKTRQT
K98 FCEIPIPKRHLLGRR
- gap
T188 QKPLEAKTKSVKSPS
S190 PLEAKTKSVKSPSWS
S193 AKTKSVKSPSWSTAE
S195 TKSVKSPSWSTAEQE
S197 SVKSPSWSTAEQEVK
S211 KRIESSHSTSRSYQD
S215 SSHSTSRSYQDPAHT
D218 STSRSYQDPAHTVTP
T224 QDPAHTVTPNAMKSL
L249 MRLSRKILCDSLDSQ
S252 SRKILCDSLDSQKTC
S255 ILCDSLDSQKTCKRR
S266 CKRRAAFSETTSPPK
S270 AAFSETTSPPKKPQP
P272 FSETTSPPKKPQPGE
K281 KPQPGEIKTSSALET
S283 QPGEIKTSSALETLG
F299 NGHTQPFFAKSSMVL
K314 RTRGTAVKTTKLTVE
K314 RTRGTAVKTTKLTVE
T316 RGTAVKTTKLTVESA
S325‑p LTVESALsPVRSRSR
R328 ESALsPVRSRSRYSV
S338 SRYSVAPSVGLTPQY
T342 VAPSVGLTPQYIGRK
K351 QYIGRKAKEQETHKE
H361 ETHKEPIHTSLRARR
T362 THKEPIHTSLRARRR
S363 HKEPIHTSLRARRRS
S370 SLRARRRSsLLTLKR
S371‑p LRARRRSsLLTLKRI
T374 RRRSsLLTLKRIKQQ
S404 SISSVEVSDSSSEEE
S406 SSVEVSDSSSEEEDE
S407 SVEVSDSSSEEEDES
S408 VEVSDSSSEEEDESV
S414 SSEEEDESVPSPPTG
P436 TRRTASKPSSQTPSK
S437 RRTASKPSSQTPSKS
T440 ASKPSSQTPSKSPKK
S442 KPSSQTPSKSPKKTF
T448 PSKSPKKTFRPRPPL
D463 HATPQIRDRNLAVQE
N465 TPQIRDRNLAVQEPA
K590 HAAELLAKQFCSRGS
S597 KQFCSRGSQKETTVL
S837 LRVRLNVSQNDVLYA
K846 NDVLYALKEE_____
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