a receptor tyrosine kinase of the Tie family. Receptor for angiopoietin 1. Expressed almost exclusively in endothelial cells. May constitute the earliest mammalian endothelial cell lineage marker. Appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 220.127.116.11; Membrane protein, integral; Kinase, protein; TK group; Tie family
Molecular Function: protein binding; protein kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor activity
Biological Process: angiogenesis; cell-cell signaling; endothelial cell proliferation; heart development; leukocyte migration; MAPKKK cascade; negative regulation of angiogenesis; negative regulation of apoptosis; negative regulation of inflammatory response; peptidyl-tyrosine phosphorylation; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; positive regulation of focal adhesion formation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade; protein amino acid autophosphorylation; protein oligomerization; regulation of establishment and/or maintenance of cell polarity; regulation of vascular permeability; signal transduction; sprouting angiogenesis; Tie receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.