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Protein Page:
TIE2 (human)

Overview
TIE2 a receptor tyrosine kinase of the Tie family. Receptor for angiopoietin 1. Expressed almost exclusively in endothelial cells. May constitute the earliest mammalian endothelial cell lineage marker. Appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Tie family
Chromosomal Location of Human Ortholog: 9p21
Cellular Component: actin filament; apical plasma membrane; basal plasma membrane; basolateral plasma membrane; cell surface; extracellular region; focal adhesion; integral to plasma membrane; intercellular junction; lipid raft; microvillus; perinuclear region of cytoplasm; plasma membrane; stress fiber
Molecular Function: ATP binding; growth factor binding; protein binding; protein kinase activity; protein-tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: activation of MAPKK activity; angiogenesis; axon guidance; blood coagulation; cell-cell adhesion; cell-cell signaling; cell-matrix adhesion; endochondral ossification; endothelial cell proliferation; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; heart development; innate immune response; insulin receptor signaling pathway; leukocyte migration; MAPKKK cascade; negative regulation of angiogenesis; negative regulation of apoptosis; negative regulation of inflammatory response; nerve growth factor receptor signaling pathway; organ regeneration; peptidyl-tyrosine phosphorylation; positive regulation of angiogenesis; positive regulation of cytokine secretion during immune response; positive regulation of endothelial cell proliferation; positive regulation of focal adhesion formation; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; positive regulation of protein import into nucleus; positive regulation of protein kinase B signaling cascade; protein amino acid autophosphorylation; protein oligomerization; Ras protein signal transduction; regulation of establishment and/or maintenance of cell polarity; regulation of vascular permeability; response to cAMP; response to estrogen stimulus; response to hypoxia; signal transduction; small GTPase mediated signal transduction; sprouting angiogenesis; Tie receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway
Disease: Venous Malformations, Multiple Cutaneous And Mucosal
Reference #:  Q02763 (UniProtKB)
Alt. Names/Synonyms: Angiopoietin-1 receptor; CD202B; hTIE2; p140 TEK; soluble TIE2 variant 1; soluble TIE2 variant 2; TEK; TEK tyrosine kinase, endothelial; TIE-2; TIE2; Tunica interna endothelial cell kinase; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; VMCM; VMCM1
Gene Symbols: TEK
Molecular weight: 125,830 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TIE2

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: Y1102‑p
enzymatic activity, induced: Y1102‑p, Y1108‑p, S1119‑p
enzymatic activity, inhibited: Y897‑p
molecular association, regulation: Y1102‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T115‑p GEAIRIRtMKMRQQA
0 1 S142‑p KGDNVNIsFKKVLIK
0 1 S164‑p KNGSFIHsVPRHEVP
0 1 Y697‑p KNATITQyQLKGLEP
0 1 Y816‑p NNPDPTIyPVLDWND
1 26 Y897‑p GACEHRGyLyLAIEY
0 1 Y899‑p CEHRGyLyLAIEYAP
0 11 Y976‑p NILVGENyVAKIADF
3 0 Y992‑p LSRGQEVyVKKTMGR
1 0 Y1048‑p GMTCAELyEKLPQGY
5 0 Y1102‑p MLEERKTyVNTTLyE
4 1 Y1108‑p TyVNTTLyEKFTyAG
3 0 Y1113‑p TLyEKFTyAGIDCsA
2 2 S1119‑p TyAGIDCsAEEAA__
4221 : Phospho-Tie2 (Tyr992) Antibody
4226 : Phospho-Tie2 (Ser1119) Antibody
  mouse

 
T115 GQAIRIRTMKMRQQA
S142 RGDNVNISFKKVLIK
S164 KNGSFIHSVPRHEVP
Y696 KNATVTQYQLKGLEP
Y814 NNPDPTIYPVLDWND
Y895 GACEHRGYLYLAIEY
Y897 CEHRGYLYLAIEYAP
Y974 NILVGENYIAKIADF
Y990 LSRGQEVYVKKTMGR
Y1046 GMTCAELYEKLPQGY
Y1100‑p MLEERKTyVNTTLyE
Y1106‑p TyVNTTLyEKFTyAG
Y1111‑p TLyEKFTyAGIDCsA
S1117‑p TyAGIDCsAEEAA__
4221 : Phospho-Tie2 (Tyr992) Antibody
4226 : Phospho-Tie2 (Ser1119) Antibody
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