Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
STX1A (human)

STX1A a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: cytosol; integral to membrane; neuron projection; plasma membrane; SNARE complex; synaptic vesicle; voltage-gated potassium channel complex
Molecular Function: chloride channel inhibitor activity; kinase binding; myosin binding; protein binding; SNAP receptor activity; SNARE binding
Biological Process: glutamate secretion; intracellular protein transport; neurotransmitter secretion; positive regulation of calcium ion-dependent exocytosis; positive regulation of catecholamine secretion; regulation of insulin secretion; secretion by cell; synaptic vesicle fusion to presynaptic membrane; vesicle docking
Reference #:  Q16623 (UniProtKB)
Alt. Names/Synonyms: HPC-1; Neuron-specific antigen HPC-1; P35-1; STX1; STX1A; SYN1A; syntaxin 1A (brain); Syntaxin-1A
Gene Symbols: STX1A
Molecular weight: 33,023 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein