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Protein Page:
MCPH1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MCPH1 a DNA damage responsive protein and transcriptional repressor of human telomere reverse transcriptase. An early responder to DNA damage. Required for double strand break repair via homologous recombination and nonhomologous end joining. Promotes chromatin relaxation by recruiting and maintaining the chromatin remodeling SWI-SNF complex at sites of DNA double strand breakage. Participates in the ATR/Chk1-mediated DNA checkpoint in humans and transcriptionally regulates BRCA1 and Chk1. Plays a role in neurogenesis and regulation of the size of the cerebral cortex. Mutations of MCPH1 can cause microcephaly in humans and appears to play an evolutionarily conserved role in brain development. Alterations have been identified in breast, ovarian and prostate cancer. Appears to coordinate S-M transitions in fly embryos. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: nucleoplasm
Molecular Function: identical protein binding; protein binding
Disease: Microcephaly 1, Primary, Autosomal Recessive
Reference #:  Q8NEM0 (UniProtKB)
Alt. Names/Synonyms: BRCT-repeat inhibitor of TERT expression 1; BRIT1; FLJ12847; MCPH1; MCT; Microcephalin; microcephalin 1
Gene Symbols: MCPH1
Molecular weight: 92,877 Da
Basal Isoelectric point: 8.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MCPH1

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S102‑p NMNEHLSsLIKKKRK
0 5 T120‑p PKDFNFKtPENDKRF
0 6 T143‑p KELQRQKtNLDDDVP
0 3 S156 VPILLFESNGSLIYT
0 4 T165 GSLIYTPTIEINSRH
0 1 S191‑p KEKRENLsPTSSQMI
0 3 S254‑p QERKLEGsINDIKSD
0 2 S266 KSDVCISSLVLKANN
0 1 N273 SLVLKANNIHssPsF
0 2 S276‑p LKANNIHssPsFtHL
0 3 S277‑p KANNIHssPsFtHLD
0 5 S279‑p NNIHssPsFtHLDKS
0 1 T281‑p IHssPsFtHLDKSsP
0 2 S287‑p FtHLDKSsPQKFLSN
0 3 N294 sPQKFLSNLSKEEIN
0 1 S296 QKFLSNLSKEEINLQ
0 1 K309‑ac LQRNIAGkVVtPDQK
0 1 T312‑p NIAGkVVtPDQKQAA
1 1 S322‑p QKQAAGMsQETFEEK
0 9 S333‑p FEEKYRLsPtLsstK
0 4 T335‑p EKYRLsPtLsstKGH
0 3 S337‑p YRLsPtLsstKGHLL
0 1 S338‑p RLsPtLsstKGHLLI
0 1 T339‑p LsPtLsstKGHLLIH
0 1 S365‑p RVSHGSHsPPKEKCK
0 3 K368 HGSHsPPKEKCKRKR
0 1 K370 SHsPPKEKCKRKRST
0 3 S406‑p GPALEALsCGESSYD
0 1 S437‑p PPESQLPssPAQLSC
0 3 S438‑p PESQLPssPAQLSCR
0 1 S526 CPEGNGFSYTIEDPA
0 1 Y527 PEGNGFSYTIEDPAL
0 1 - gap
0 2 T543‑p KGHDDDLtPLEGsLE
0 5 S548‑p DLtPLEGsLEEMKEA
0 1 T561 EAVGLKSTQNKGTTS
0 1 S573 TTSKISNSSEGEAQS
0 2 Y606 KENLPGGYSGSVKNR
0 2 S609 LPGGYSGSVKNRPTR
0 1 S623‑p RHDVLDDsCDGFKDL
0 2 R642 EELKKSGRGKKPTRT
0 1 T653‑p PTRTLVMtSMPsEKQ
0 1 S657‑p LVMtSMPsEKQNVVI
0 1 S787‑p HLCGGRVsQVPRQAs
0 2 S794‑p sQVPRQAsIVIGPYS
  MCPH1 iso2  
S102 NMNEHLSSLIKKKRK
T120 PKDFNFKTPENDKRF
T143 KELQRQKTNLASQMI
- gap
- gap
- gap
S206 QERKLEGSINDIKSD
S218 KSDVCISSLVLKANN
N225 SLVLKANNIHSSPSF
S228 LKANNIHSSPSFTHL
S229 KANNIHSSPSFTHLD
S231 NNIHSSPSFTHLDKS
T233 IHSSPSFTHLDKSSP
S239 FTHLDKSSPQKFLSN
N246 SPQKFLSNLSKEEIN
S248 QKFLSNLSKEEINLQ
K261 LQRNIAGKVVTPDQK
T264 NIAGKVVTPDQKQAA
S274 QKQAAGMSQETFEEK
S285 FEEKYRLSPTLSSTK
T287 EKYRLSPTLSSTKGH
S289 YRLSPTLSSTKGHLL
S290 RLSPTLSSTKGHLLI
T291 LSPTLSSTKGHLLIH
S317 RVSHGSHSPPKEKCK
K320 HGSHSPPKEKCKRKR
K322 SHSPPKEKCKRKRST
S358 GPALEALSCGESSYD
S389 PPESQLPSSPAQLSC
S390 PESQLPSSPAQLSCR
S478 CPEGNGFSYTIEDPA
Y479 PEGNGFSYTIEDPAL
- gap
T495 KGHDDDLTPLEGSLE
S500 DLTPLEGSLEEMKEA
T513 EAVGLKSTQNKGTTS
S525 TTSKISNSSEGEAQS
Y558 KENLPGGYSGSM___
S561 LPGGYSGSM______
- gap
- gap
- gap
- gap
- gap
- gap
  MCPH1 iso3  
S102 NMNEHLSSLIKKKRK
T120 PKDFNFKTPENDKRF
T143‑p KELQRQKtNLDDDVP
S156 VPILLFESNGSLIYT
T165 GSLIYTPTIEINSRH
S191 KEKRENLSPTSSQMI
S254 QERKLEGSINDIKSD
S266 KSDVCISSLVLKANN
N273 SLVLKANNIHSSPSF
S276 LKANNIHSSPSFTHL
S277 KANNIHSSPSFTHLD
S279 NNIHSSPSFTHLDKS
T281 IHSSPSFTHLDKSSP
S287 FTHLDKSSPQKFLSN
N294 SPQKFLSNLSKEEIN
S296 QKFLSNLSKEEINLQ
K309 LQRNIAGKVVTPDQK
T312 NIAGKVVTPDQKQAA
S322 QKQAAGMSQETFEEK
S333 FEEKYRLSPTLSSTK
T335 EKYRLSPTLSSTKGH
S337 YRLSPTLSSTKGHLL
S338 RLSPTLSSTKGHLLI
T339 LSPTLSSTKGHLLIH
S365 RVSHGSHSPPKEKCK
K368 HGSHSPPKEKCKRKR
K370 SHSPPKEKCKRKRST
S406 GPALEALSCGESSYD
S437 PPESQLPSSPAQLSC
S438 PESQLPSSPAQLSCR
S526 CPEGNGFSYTIEDPA
Y527 PEGNGFSYTIEDPAL
- gap
T543 KGHDDDLTPLEGSLE
S548 DLTPLEGSLEEMKEA
T561 EAVGLKSTQNKGTTS
S573 TTSKISNSSEGEAQS
Y606‑p KENLPGGySGsM___
S609‑p LPGGySGsM______
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
N108 NTDEHLPNLSRKKHK
T126 PKDFILKTPENDKRL
A149 EELQRQKAALDDDVP
S162‑p VPVLLFEsPRSLVYS
S170‑p PRSLVYSsPVNVMKR
S190 KEKRENLSPTSSQML
S248‑p QERKLGRsANEMTTV
S260‑p TTVTCPSsPVLRASs
S267‑p sPVLRASsFYGsAsP
G270 LRASsFYGsAsPNHL
S271‑p RASsFYGsAsPNHLR
S273‑p SsFYGsAsPNHLRQP
N275 FYGsAsPNHLRQPRP
R281 PNHLRQPRPQKAPDs
S288‑p RPQKAPDsPsKESIN
S290‑p QKAPDsPsKESINCQ
A303 CQKDATGAVADSERK
S307 ATGAVADSERKQAAG
S316 RKQAAGVSQGVPDEK
S327‑p PDEKLCLsPtMsIIE
T329‑p EKLCLsPtMsIIEEH
S331‑p LCLsPtMsIIEEHQV
I332 CLsPtMsIIEEHQVR
I333 LsPtMsIIEEHQVRL
S357 KRAADLGSSPkGkLK
K360‑ac ADLGSSPkGkLKKRY
K362‑ac LGSSPkGkLKKRYKR
D396 RLIPGTPDVEASSYE
A427 PPEAQQLAsPSLFHC
S428‑p PEAQQLAsPSLFHCR
S520‑p DDTGPEGssHPDTLS
S521‑p DTGPEGssHPDTLSS
S529‑p HPDTLSSsAHHITPL
T534 SSsAHHITPLKGNST
S540 ITPLKGNSTETRDPG
S552‑p DPGDGKGsPKEGSTP
S564 STPPASASPEDEVHI
Y596 KENIATGYSESVKNG
S599 IATGYSESVKNGPGR
S613 RPDPSDSSCTGLVRP
K629‑ac QKPKKSEkEEKPTRT
T640 PTRTLVMTSMPSEKQ
S644 LVMTSMPSEKQTLII
S774 LLCGGQVSPAPQLAS
S781 SPAPQLASLIIGPYK
  rat

 
N108 NTDEHLPNLIRRKHK
T126 PKDFIPKTPENDKRL
A149 EELQRQKAALDDDVP
S162 VPVLMFESPQSLVYS
S170 PQSLVYSSPVNMMKK
S190 KEKRENLSPTSSQML
S248 QERKLGRSSNEMARM
S260 ARMTCPSSPVLRASS
S267 SPVLRASSFYGSASS
G270 LRASSFYGSASSNHL
S271 RASSFYGSASSNHLR
S273 SSFYGSASSNHLRQP
N275 FYGSASSNHLRQPSP
S281 SNHLRQPSPQKAADT
T288 SPQKAADTPSKEGVN
S290 QKAADTPSKEGVNQQ
E303 QQKEATSEVTDSKRK
S307 ATSEVTDSKRKQAAG
S316 RKQAAGVSQGMADEK
S327 ADEKHCLSPTKSVIE
T329 EKHCLSPTKSVIEER
S331 HCLSPTKSVIEERVV
V332 CLSPTKSVIEERVVH
I333 LSPTKSVIEERVVHL
S357 KRTADLGSPSKGKLK
K360 ADLGSPSKGKLKKRY
K362 LGSPSKGKLKKRYKR
D396 RPIPGTPDVEASSYE
A426 LPEAQLLASPSLFRC
S427 PEAQLLASPSLFRCK
S518 EDTGPEGSSHPDILY
S519 DTGPEGSSHPDILYS
S526 SHPDILYSPAHHITP
T532 YSPAHHITPLKGSST
S538 ITPLKGSSTETRDPG
S550 DPGDGKGSPKEGTTP
S562‑p TTPPASAsPEGEAHS
Y590 KENVATGYPGSVKNG
S593 VATGYPGSVKNGLGR
S607 RPDPSDSSYRGLVRP
K623 EKPKNSGKEKEPTRT
T634 PTRTLVMTSMPSEQQ
S638 LVMTSMPSEQQDLII
S768 LLCGGQVSPAPQLAS
S775 SPAPQLASLIIGPYK
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