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Protein Page:
FZD5 (human)

Overview
FZD5 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. Interacts with GOPC. Belongs to the G-protein coupled receptor Fz/Smo family. Note: This description may include information from UniProtKB.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, Fz/Smo family; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q33.3
Cellular Component: cell surface; early endosome membrane; Golgi membrane; integral to membrane; perinuclear region of cytoplasm; plasma membrane; tight junction
Molecular Function: beta-amyloid binding; G-protein coupled receptor activity; protein binding; protein kinase binding; ubiquitin protein ligase binding; Wnt receptor activity; Wnt-protein binding
Biological Process: angiogenesis; cell maturation; determination of anterior/posterior axis, embryo; embryonic axis specification; embryonic camera-type eye morphogenesis; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; neuron differentiation; positive regulation of interferon-gamma production; positive regulation of JNK activity; positive regulation of T cell cytokine production; positive regulation of transcription from RNA polymerase II promoter; post-embryonic camera-type eye development; Spemann organizer formation; synaptogenesis; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, calcium modulating pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Reference #:  Q13467 (UniProtKB)
Gene Symbols: FZD5
Molecular weight: 64,507 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FZD5

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S7‑p _MARPDPsAPPsLLL
0 1 S11‑p PDPsAPPsLLLLLLA
0 1 S399 VGNQNLNSLRGFVLG
0 1 T440‑p IKQGGTKtDKLEKLM
0 5 Y556‑p GAMAAGDyPEASAAL
0 7 T575‑p GPPGPAAtyHKQVsL
0 17 Y576‑p PPGPAAtyHKQVsLS
0 1 S581‑p AtyHKQVsLSHV___
  mouse

 
S7 _MARPDPSAPPSLLL
S11 PDPSAPPSLLLLLLA
S399 VGNQNLNSLRGFVLG
T440 IKQGGTKTDKLEKLM
Y556 GAMAAGDYAEASAAL
A575 GPPGPTAAYHKQVsL
Y576 PPGPTAAYHKQVsLS
S581‑p AAYHKQVsLSHV___
  rat

 
S7 _MARPDPSAPPSLLL
S11 PDPSAPPSLLLLLLA
S399‑p VGNQNLNsLRGFVLG
T440 IKQGGTKTDKLEKLM
Y556 GAMVAGDYAEASAAL
A575 GPPGPAAAYHKQVSL
Y576 PPGPAAAYHKQVSLS
S581 AAYHKQVSLSHV___
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