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Protein Page:
CSK (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CSK a tyrosine kinase of the Csk family that phosphorylates and inhibits Src family kinases. Specifically phosphorylates Y504 on LCK, which acts as a negative regulatory site. Csk and the phospho-tyrosine phosphatase CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn during T-cell receptor mediated signaling during thymic development. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; TK group; Csk family
Chromosomal Location of Human Ortholog: 15q24.1
Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; intercellular junction; lipid raft; plasma membrane
Molecular Function: ATP binding; identical protein binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein C-terminus binding; protein phosphatase binding; protein-tyrosine kinase activity; receptor binding
Biological Process: adaptive immune response; brain development; cell differentiation; cell migration; central nervous system development; epidermal growth factor receptor signaling pathway; innate immune response; negative regulation of bone resorption; negative regulation of cell proliferation; negative regulation of Golgi to plasma membrane protein transport; negative regulation of interleukin-6 production; negative regulation of kinase activity; negative regulation of phagocytosis; oligodendrocyte differentiation; positive regulation of MAP kinase activity; protein amino acid phosphorylation; regulation of cell proliferation; regulation of cytokine production; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P41240 (UniProtKB)
Alt. Names/Synonyms: C-Src kinase; c-src tyrosine kinase; CSK; MGC117393; Protein-tyrosine kinase CYL; Tyrosine-protein kinase CSK
Gene Symbols: CSK
Molecular weight: 50,704 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CSK

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S364‑p
phosphorylation: S364‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T23‑p AKYNFHGtAEQDLPF
0 1 K43‑ub LTIVAVTkDPNWYKA
0 6 Y64‑p EGIIPANyVQKREGV
0 1 K76‑ub EGVKAGTkLSLMPWF
0 2 Y97‑p EQAERLLyPPETGLF
0 1 K171‑ub CTRLIKPkVMEGtVA
0 1 T176‑p KPkVMEGtVAAQDEF
1 40 Y184‑p VAAQDEFyRsGWALN
0 1 S186‑p AQDEFyRsGWALNMk
0 2 K193‑ub sGWALNMkELkLLQT
0 3 K196‑ub ALNMkELkLLQTIGk
0 6 K203‑ub kLLQTIGkGEFGDVM
0 7 K222‑ub RGNKVAVkCIKNDAT
0 1 Y263‑p VEEKGGLyIVTEYMA
0 6 Y277‑p AKGSLVDyLRSRGRs
0 2 S284‑p yLRSRGRsVLGGDCL
0 1 K329‑ub VSEDNVAkVSDFGLT
0 1 K337‑ub VSDFGLTkEASSTQD
0 1 K347‑ub SSTQDTGkLPVKWTA
3 0 S364‑p ALREKKFsTKSDVWS
0 3 K393‑ub PYPRIPLkDVVPRVE
0 1 Y416‑p DGCPPAVyEVMKNCW
  mouse

 
T23 AKYNFHGTAEQDLPF
K43 LTIVAVTKDPNWYKA
Y64 EGIIPANYVQKREGV
K76 EGVKAGTKLSLMPWF
Y97‑p EQAERLLyPPETGLF
K171 CTRLIKPKVMEGTVA
T176 KPKVMEGTVAAQDEF
Y184‑p VAAQDEFyRSGWALN
S186 AQDEFyRSGWALNMK
K193 SGWALNMKELKLLQT
K196 ALNMKELKLLQTIGK
K203 KLLQTIGKGEFGDVM
K222 RGNKVAVKCIKNDAT
Y263 VEEKGGLYIVTEYMA
Y277 AKGSLVDYLRSRGRS
S284 YLRSRGRSVLGGDCL
K329 VSEDNVAKVSDFGLT
K337 VSDFGLTKEASSTQD
K347 SSTQDTGKLPVKWTA
S364 ALREKKFSTKSDVWS
K393 PYPRIPLKDVVPRVE
Y416 DGCPPAVYEVMKNCW
  rat

 
T23 AKYNFHGTAEQDLPF
K43 LTIVAVTKDPNWYKA
Y64 EGIIPANYVQKREGV
K76 EGVKAGTKLSLMPWF
Y97 EQAERLLYPPETGLF
K171 CTRLIKPKVMEGTVA
T176 KPKVMEGTVAAQDEF
Y184 VAAQDEFYRSGWALN
S186 AQDEFYRSGWALNMK
K193 SGWALNMKELKLLQT
K196 ALNMKELKLLQTIGK
K203 KLLQTIGKGEFGDVM
K222 RGNKVAVKCIKNDAT
Y263 VEEKGGLYIVTEYMA
Y277 AKGSLVDYLRSRGRS
S284 YLRSRGRSVLGGDCL
K329 VSEDNVAKVSDFGLT
K337 VSDFGLTKEASSTQD
K347 SSTQDTGKLPVKWTA
S364 ALREKKFSTKSDVWS
K393 PYPRIPLKDVVPRVE
Y416 DGCPPAVYDVMKNCW
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