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Protein Page:
AKAP5 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AKAP5 May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C. Interacts with ADCY8, and enhances its phosphorylation at lipid rafts. Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 14q23.3
Cellular Component: asymmetric synapse; basolateral plasma membrane; cell soma; cytoskeleton; cytosol; dendritic shaft; dendritic spine; filopodium membrane; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; protein complex
Molecular Function: actin binding; adenylate cyclase binding; cadherin binding; calmodulin binding; G-protein-coupled receptor binding; GABA receptor binding; protein binding; protein complex binding; protein domain specific binding; protein kinase A binding; protein kinase binding; protein phosphatase 2B binding
Biological Process: cellular protein complex disassembly; energy reserve metabolic process; hippocampus development; maternal process involved in pregnancy; negative regulation of adenylate cyclase activity; negative regulation of potassium ion transport; positive regulation of adenylate cyclase activity; positive regulation of cAMP biosynthetic process; positive regulation of dendrite morphogenesis; positive regulation of NFAT protein import into nucleus; positive regulation of protein amino acid phosphorylation; protein targeting; regulation of insulin secretion; response to electrical stimulus; response to muscle activity; signal transduction; spinal cord development; synaptic transmission
Reference #:  P24588 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein 5; A-kinase anchor protein 5; A-kinase anchor protein 79 kDa; A-kinase anchor protein, 79kDa; A-kinase anchoring protein 75/79; AKAP 79; AKAP-5; AKAP5; AKAP75; AKAP79; cAMP-dependent protein kinase regulatory subunit II high affinity binding protein; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; H21
Gene Symbols: AKAP5
Molecular weight: 47,088 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AKAP5

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 T4 ____METTISEIHVE
0 2 S6 __METTISEIHVENK
0 1 S18‑p ENKDEKRsAEGsPGA
0 5 S22‑p EKRsAEGsPGAERQK
0 1 K48 KKAAKALKPKAGsEA
0 1 K50 AAKALKPKAGsEAAD
0 2 S53‑p ALKPKAGsEAADVAR
0 1 S69‑p CPQEAGAsDQPEPTR
0 1 S81‑p PTRGAWAsLKRLVTR
0 1 S92‑p LVTRRKRsESsKQQK
0 1 S95‑p RRKRsESsKQQKPLE
0 1 S148 HSKIIEDSDCsIKVQ
0 2 S151‑p IIEDSDCsIKVQEEA
0 5 S178‑p DQATKAKsTQDLSEG
0 5 T227 HSAIQTGTLILEEIE
0 5 S248 DVQPQQASPLETSET
0 5 H257 LETSETDHQQPVLSD
0 3 - gap
  AKAP5 iso2  
T4 ____METTISEIHVE
S6 __METTISEIHVENK
S18 ENKDEKRSAEGSPGA
S22 EKRSAEGSPGAERQK
K48 KKAAKALKPKAGSEA
K50 AAKALKPKAGSEAAD
S53 ALKPKAGSEAADVAR
S69 CPQEAGASDQPEPTR
S81 PTRGAWASLKRLVTR
S92 LVTRRKRSESSKQQK
S95 RRKRSESSKQQKPLE
S148 HSKIIEDSDCSIKVQ
S151 IIEDSDCSIKVQEEA
S178 DQATKAKSTQDLSEG
T227 HSAIQTGTLILEEIE
S248 DVQPQQASPLETSET
H257 LETSETDHQQPVLSD
- gap
  mouse

 
S4‑p ____METsVsEIQVE
S6‑p __METsVsEIQVETK
P18 ETKDEKGPVAAsPQK
S22‑p EKGPVAAsPQKERQE
K47 RKKANKTKPKAGSRT
K49 KANKTKPKAGSRTAE
S52 KTKPKAGSRTAEETK
S68 HTPEAGGSGQRQPAG
S79 QPAGAWASIKGLVTH
S90 LVTHRKRSEPAKKQK
A93 HRKRSEPAKKQKPPE
S142‑p HSKLTEDsGyVRVQG
Y144‑p KLTEDsGyVRVQGEA
S171 DQAIQAGSTQGLQEG
T220‑p SSAIQMGtPELEKET
S242‑p SVQTQRAsLLESSAA
S251‑p LESSAAGsPRSVTSA
S349‑p QAKEGKLsQAEETTV
  rat

 
S4 ____METSVSEIQIE
S6 __METSVSEIQIETK
P18 ETKDEKRPEAAsPQK
S22‑p EKRPEAAsPQKERQE
K47‑ac RKKVNKKkAkAGSKT
K49‑ac KVNKKkAkAGSKTAE
S52 KKkAkAGSKTAEETE
S68 HAPEAGGSGQRQPAG
S79 QPAGAWASIKRLVTH
S90 LVTHRKPSESAEKQK
A93 HRKPSESAEKQKPSE
S142 PSKLTEDSGYVRVQG
Y144 KLTEDSGYVRVQGEA
S171 EQATQAKSTQGLQED
T220 SSALRMRTPGSEKEA
S242 GVQVQEASVLENSAA
S251 LENSAADSPQPVTST
S351 QAKEGKLSQAEEATV
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