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Protein Page:
OPHN1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
OPHN1 Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Defects in OPHN1 are the cause of mental retardation X- linked OPHN1-related (MRXSO); formerly designated MRX60. MRXSO is a syndromic mental retardation. Patients present mental retardation associated with cerebellar hypoplasia and distinctive facial dysmorphism. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; GAPs, Rac/Rho; GAPs
Chromosomal Location of Human Ortholog: Xq12
Cellular Component: cytosol
Molecular Function: GTPase activator activity; phospholipid binding
Biological Process: axon guidance; nervous system development; regulation of small GTPase mediated signal transduction; substrate-bound cell migration, cell extension
Disease: Mental Retardation, X-linked, With Cerebellar Hypoplasia And Distinctive Facial Appearance
Reference #:  O60890 (UniProtKB)
Alt. Names/Synonyms: ARHGAP41; mental retardation, X-linked 60; MRX60; oligophrenin 1; Oligophrenin-1; oligophrenin-1, Rho-GTPase activating protein; OPHN1; OPN1
Gene Symbols: OPHN1
Molecular weight: 91,641 Da
Basal Isoelectric point: 8.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

OPHN1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K37‑ac ERTNKFIkDVIKDGN
0 1 T218 NSLTVELTQDFLPYK
0 151 Y370‑p MDGKEPIyHsPITKQ
0 1 S372‑p GKEPIyHsPITKQQE
0 1 Y480‑p AKSDNLDyRLGAIHS
0 1 T531‑p MGVIFGPtLMRAQED
0 1 S592 RHKPITISKRLLRER
0 6 S652‑p ETDPGRKsPSRPILD
0 1 T685‑p QDGGTKItPKATNGP
0 1 S696‑p TNGPMPGsGPTKTPs
0 3 S703‑p sGPTKTPsFHIKRPA
0 2 T753‑p DPPCRAAtPQKPEPK
  mouse

 
K37 ERTNKFIKDVIKDGS
T218‑p NSLTVELtQDFLPYK
Y370‑p MDGKEPIyHTPITKQ
T372 GKEPIyHTPITKQEE
Y480 AKSDNLDYRLGAIHS
T531 MGVIFGPTLMRAQED
S592‑p RHKPITIsKRLLREK
S652 ETDPGRKSPSRPVSD
T685 QDGGTKATPKASNGP
S696 SNGPVPGSGHTKTSs
S703‑p SGHTKTSsFHIRRPA
T753 DPPCRSITPQKPEPK
  rat

 
K37 ERTNKFIKDVIKDGS
T218 NSLTVELTQDFLPYK
Y370 MDGKEPIYHSPITKQ
S372 GKEPIYHSPITKQEE
Y480 AKSDNLDYRLGAIHS
T531 MGVIFGPTLMRAQED
S592 RHKPITISKRLLREK
S652 EMDPGRKSPSRPVSD
I685 QDGGTKAIPKASNGP
S696 SNGPVPGSGHTKTSS
S703 SGHTKTSSFHIKRPA
T753 DPPCRSSTSQKPESK
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