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Protein Page:
IRF2 (human)

IRF2 Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity. By viruses and IFN. Expressed throughout the epithelium of the colon. Also expressed in lamina propria. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 4q34.1-q35.1
Cellular Component: cytoplasm; cytosol; focal adhesion; nucleoplasm
Molecular Function: DNA binding; protein binding; transcription factor activity
Biological Process: blood coagulation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent
Reference #:  P14316 (UniProtKB)
Alt. Names/Synonyms: DKFZp686F0244; Interferon regulatory factor 2; IRF-2; IRF2
Gene Symbols: IRF2
Molecular weight: 39,354 Da
Basal Isoelectric point: 7.07  Predict pI for various phosphorylation states
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