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Protein Page:
H2AZ (human)

H2AZ Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP. Belongs to the histone H2A family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 4q24
Cellular Component: Barr body; nuclear heterochromatin; nucleus
Molecular Function: chromatin DNA binding; nucleosomal DNA binding; protein binding
Biological Process: chromatin silencing; positive regulation of transcription from RNA polymerase II promoter
Reference #:  P0C0S5 (UniProtKB)
Alt. Names/Synonyms: H2A histone family, member Z; H2A.z; H2A/z; H2AFZ; H2AZ; H2AZ histone; Histone H2A.Z; MGC117173
Gene Symbols: H2AFZ
Molecular weight: 13,422 Da
Basal Isoelectric point: 10.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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