an SH2-containing ubiquitously expressed tyrosine-specific protein phosphatase. Plays a key role in hematopoiesis. Directly links growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 22.214.171.124
Molecular Function: phosphotyrosine binding; protein binding; protein kinase binding; protein tyrosine phosphatase activity; SH2 domain binding; SH3 domain binding; transmembrane receptor protein tyrosine phosphatase activity
Biological Process: abortive mitotic cell cycle; apoptosis; B cell receptor signaling pathway; cell differentiation; cell proliferation; G-protein coupled receptor protein signaling pathway; leukocyte migration; natural killer cell mediated cytotoxicity; negative regulation of B cell receptor signaling pathway; negative regulation of cell proliferation; negative regulation of humoral immune response mediated by circulating immunoglobulin; negative regulation of MAP kinase activity; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; peptidyl-tyrosine phosphorylation; platelet activation; platelet formation; positive regulation of cell adhesion mediated by integrin; positive regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; protein amino acid dephosphorylation; regulation of B cell differentiation; regulation of release of sequestered calcium ion into cytosol; T cell costimulation
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.