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Protein Page:
PDCD8 (human)

PDCD8 Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase- independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. Interacts with XIAP/BIRC4. Interacts (via N-terminus) with EIF3G (via C-terminus). Belongs to the FAD-dependent oxidoreductase family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC 1.-.-.-; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: Xq26.1
Cellular Component: cytosol; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion; nucleus
Molecular Function: electron carrier activity; NAD(P)H oxidase activity; oxidoreductase activity, acting on NADH or NADPH; protein binding
Biological Process: apoptosis; caspase activation; chromosome condensation; DNA catabolic process; positive regulation of apoptosis
Disease: Deafness, X-linked 5
Reference #:  O95831 (UniProtKB)
Alt. Names/Synonyms: AIF; AIFM1; Apoptosis-inducing factor 1, mitochondrial; apoptosis-inducing factor, mitochondrion-associated, 1; MGC111425; PDCD8; programmed cell death 8 (apoptosis-inducing factor); Programmed cell death protein 8; striatal apoptosis-inducing factor
Gene Symbols: AIFM1
Molecular weight: 66,901 Da
Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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