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Protein Page:
ITGAV (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ITGAV The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q31-q32
Cellular Component: cell surface; external side of plasma membrane; filopodium membrane; focal adhesion; integral to plasma membrane; integrin complex; membrane; microvillus membrane; phagocytic vesicle; plasma membrane
Molecular Function: extracellular matrix binding; fibronectin binding; insulin-like growth factor I binding; metal ion binding; opsonin binding; protease binding; protein binding; protein kinase C binding; transforming growth factor beta binding; viral receptor activity; voltage-gated calcium channel activity
Biological Process: angiogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; apoptotic cell clearance; axon guidance; blood coagulation; cell adhesion; cell growth; cell migration; cell-matrix adhesion; cell-substrate adhesion; entry of symbiont into host cell by promotion of host phagocytosis; entry of virus into host cell; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte migration; negative chemotaxis; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of osteoblast proliferation; regulation of phagocytosis; vascular endothelial growth factor receptor signaling pathway
Reference #:  P06756 (UniProtKB)
Alt. Names/Synonyms: antigen identified by monoclonal antibody L230; CD51; DKFZp686A08142; Integrin alpha-V; Integrin alpha-V heavy chain; Integrin alpha-V light chain; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); ITAV; ITGAV; MSK8; Vitronectin receptor subunit alpha; VNRA
Gene Symbols: ITGAV
Molecular weight: 116,038 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ITGAV

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S21‑p RGLPLLLsGLLLPLC
0 2 K233‑ub DPNVYSIkYNNQLAT
0 1 T279‑p GVPRAARtLGMVyIY
0 1 Y284‑p ARtLGMVyIYDGKNM
0 2 K360‑ub SGDFQTTkLNGFEVF
0 1 K399‑ub APYGGEDkKGIVyIF
0 1 Y404‑p EDkKGIVyIFNGRST
0 1 K446‑ub KGATDIDkNGYPDLI
0 1 K581‑ub DESEFRDkLTPItIF
0 1 T586‑p RDkLTPItIFMEyRL
0 1 Y591‑p PItIFMEyRLDYRTA
0 1 K645‑ub VSVDSDQkKIYIGDD
0 1 S749‑p KFDLQIQsSNLFDKV
0 1 S866‑p NPLRIKIsSLQTTEk
0 1 K873‑ub sSLQTTEkNDTVAGQ
0 7 S1046‑p HENGEGNsEt_____
0 2 T1048‑p NGEGNsEt_______
  mouse

 
P21 GGLLLLLPGLLLPLA
K233 DPNVYSIKYNNQLAT
T279 GVPRAARTLGMVYIY
Y284 ARTLGMVYIYDGKNM
K360 VGDFQTTKLNGFEVF
K399 APYGGEDKKGLVYIF
Y404 EDKKGLVYIFNGRST
R446 KGATDVDRNGYPDLV
K581 DESEFRDKLTPITIF
T586 RDKLTPITIFMEYRL
Y591 PITIFMEYRLDQRTA
K645 VSVNSDQKKIYIGDD
S749 KFDLKIQSSNSFDNV
- gap
K868 LRIKTPEKNDTAAAG
S1042‑p HENGEGNsEt_____
T1044‑p NGEGNsEt_______
  rat

 
L21 GGLLLLLLGLLLPFA
K233 DPNVYSIKYNNQLAT
T279 GVPRAARTLGMVYIY
Y284 ARTLGMVYIYDGKNM
K360 SGDFQTTKLNGFEVF
K399 APYGGEDKKGLVYIF
Y404 EDKKGLVYIFNGRST
R446 KGATDVDRNGYPDLV
Y580 PISKGRVYSCQMDVR
D585 RVYSCQMDVRRGYIV
Y590 QMDVRRGYIVKKPIS
K644 VSVDSDQKKIYIGDD
S748 KFDLKIQSSNSFDNV
- gap
K867 LRIKTPEKNDTAAEQ
S1040‑p HENGEGNsET_____
T1042 NGEGNsET_______
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