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Protein Page:
PLCG2 (human)

Overview
PLCG2 a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. It is a crucial enzyme in transmembrane signaling. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase
Chromosomal Location of Human Ortholog: 16q24.1
Cellular Component: cytosol; plasma membrane
Molecular Function: phosphoinositide phospholipase C activity; phospholipase C activity; protein binding
Biological Process: B cell differentiation; B cell receptor signaling pathway; inositol phosphate metabolic process; phosphatidylinositol biosynthetic process; platelet activation; release of sequestered calcium ion into cytosol; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; Wnt receptor signaling pathway
Disease: Autoinflammation, Antibody Deficiency, And Immune Dysregulation, Plcg2-associated; Familial Cold Autoinflammatory Syndrome 3
Reference #:  P16885 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; phospholipase C gamma 2; phospholipase C, gamma 2 (phosphatidylinositol-specific); phospholipase C, gamma 2 (phosphatidylyinositol-specific); Phospholipase C-gamma-2; Phospholipase C-IV; PLC-gamma-2; PLC-IV; PLCG2
Gene Symbols: PLCG2
Molecular weight: 147,870 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PLCG2

Protein Structure Not Found.
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