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Protein Page:
Bcl-9L (human)

Bcl-9L a novel beta-catenin-interacting protein that translocates beta-catenin to the nucleus, enhancing beta-catenin mediated transcription. Can play an important role in colorectal carcinogenesis. Nuclear expression of Bcl-9L is closely associated with the high nuclear grade cancer phenotype and the expression of ErbB2/HER-2 in breast cancers. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: nucleolus; nucleoplasm; nucleus
Molecular Function: beta-catenin binding
Biological Process: negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; regulation of cell morphogenesis
Reference #:  Q86UU0 (UniProtKB)
Alt. Names/Synonyms: B-cell CLL/lymphoma 9-like; B-cell CLL/lymphoma 9-like protein; B-cell lymphoma 9-like protein; BCL9-2; BCL9-like protein; BCL9L; DLNB11; nuclear co-factor of beta-catenin signalling; Protein BCL9-2
Gene Symbols: BCL9L
Molecular weight: 157,129 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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