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Protein Page:
STEP (human)

Overview
STEP a non-receptor protein-tyrosine phosphatase. STEP (striatum enriched phosphatase) Contains a single phosphatase catalytic domain located at the C-terminus. Two alternatively-spliced messages have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 11p15.1
Cellular Component: integral to membrane
Molecular Function: phosphotyrosine binding; protein binding; protein tyrosine phosphatase activity
Biological Process: protein amino acid dephosphorylation
Reference #:  P54829 (UniProtKB)
Alt. Names/Synonyms: FLJ14427; Neural-specific protein-tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched); protein-tyrosine phosphatase striatum-enriched; PTN5; PTPN5; PTPSTEP; STEP; Striatum-enriched protein-tyrosine phosphatase; Tyrosine-protein phosphatase non-receptor type 5
Gene Symbols: PTPN5
Molecular weight: 63,538 Da
Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STEP

Protein Structure Not Found.
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Download ChimeraX Script


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Sites Implicated In
enzymatic activity, inhibited: S184‑p, S245‑p
molecular association, regulation: S184‑p, S245‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S66‑p PPPPSPPsDPAQKPP
2 0 S184‑p PPEDRRQsVSRQPSF
0 2 S190 QsVSRQPSFTYSEWM
0 1 T192 VSRQPSFTYSEWMEE
0 1 Y193 SRQPSFTYSEWMEEK
9 0 S245‑p GLQERRGsNVSLTLD
1 0 T255‑p SLTLDMCtPGCNEEG
1 0 S268‑p EGFGYLMsPREESAR
0 1 Y362 NANYIRGYGGEEKVY
0 1 G363 ANYIRGYGGEEKVYI
0 1 Y369 YGGEEKVYIATQGPI
0 1 S444‑p LRLISLKsGTEERGL
5659 : Nonphospho-STEP (Ser221) (D74H3) XP(R) Rabbit mAb
  STEP iso3  
S42 PPPPSPPSDPAQKPP
S160‑p PPEDRRQsVSRQPSF
S166 QsVSRQPSFTYSEWM
T168 VSRQPSFTYSEWMEE
Y169 SRQPSFTYSEWMEEK
S221‑p GLQERRGsNVSLTLD
T231 SLTLDMCTPGCNEEG
S244 EGFGYLMSPREESAR
Y338 NANYIRGYGGEEKVY
G339 ANYIRGYGGEEKVYI
Y345 YGGEEKVYIATQGPI
S420 LRLISLKSGTEERGL
  mouse

 
S42 PPPPSPPSEPAQKLP
S160 PPEDRRQSVSRQPsF
S166‑p QSVSRQPsFtySEWM
T168‑p VSRQPsFtySEWMEE
Y169‑p SRQPsFtySEWMEEK
S221‑p GLQERRGsNVSLTLD
T231 SLTLDMCTPGCNEEG
S244 EGFGYLVSPREESAH
Y338‑p NANYIRGysGEEKVy
S339‑p ANYIRGysGEEKVyI
Y345‑p ysGEEKVyIATQGPI
R420 LRLISLRRGTEERSL
5659 : Nonphospho-STEP (Ser221) (D74H3) XP(R) Rabbit mAb
  rat

 
- gap
- gap
- gap
- gap
- gap
S49‑p GLQERRGsNVSLTLD
T59 SLTLDMCTPGCNEEG
S72 EGFGYLVSPREESAH
Y166 NANYIRGYNGEEKVY
N167 ANYIRGYNGEEKVYI
Y173 YNGEEKVYIATQGPI
R248 LRLISLRRGTEERGL
5659 : Nonphospho-STEP (Ser221) (D74H3) XP(R) Rabbit mAb
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