a non-receptor protein-tyrosine phosphatase. STEP (striatum enriched phosphatase) Contains a single phosphatase catalytic domain located at the C-terminus. Two alternatively-spliced messages have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); Membrane protein, multi-pass; EC 220.127.116.11
Cellular Component: axon; cytosol; endoplasmic reticulum membrane; integral to membrane; perikaryon
Molecular Function: glutamate receptor binding; mitogen-activated protein kinase binding; phosphotyrosine binding; protein binding; protein tyrosine phosphatase activity
Biological Process: negative regulation of MAP kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of protein import into nucleus, translocation; positive regulation of receptor internalization; protein amino acid dephosphorylation; response to amphetamine; response to drug
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.