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Protein Page:
TORC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TORC1 Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons. Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax. Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. Belongs to the TORC family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane
Molecular Function: cAMP response element binding protein binding; protein binding
Biological Process: activation of CREB transcription factor; entrainment of circadian clock by photoperiod; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q6UUV9 (UniProtKB)
Alt. Names/Synonyms: CREB regulated transcription coactivator 1; CREB-regulated transcription coactivator 1; CRTC1; FLJ14027; KIAA0616; MECT1; mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; TORC-1; TORC1; Transducer of CREB protein 1; transducer of regulated cAMP response element-binding protein (CREB) 1; Transducer of regulated cAMP response element-binding protein 1; WAMTP1
Gene Symbols: CRTC1
Molecular weight: 67,300 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TORC1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K47‑ub AARLQLQksQyLQLG
0 2 S48‑p ARLQLQksQyLQLGP
0 3 Y50‑p LQLQksQyLQLGPSR
0 3 S64‑p RGQYYGGsLPNVNQI
0 4 S113‑p RERGRLGsPHRRPLs
0 2 S120‑p sPHRRPLsVDkHGRQ
0 1 K123‑ac RRPLsVDkHGRQADs
0 1 S130‑p kHGRQADsCPYGTMY
0 3 Y133 RQADsCPYGTMYLsP
0 1 Y137 sCPYGTMYLsPPADT
0 12 S139‑p PYGTMYLsPPADTSW
0 4 T149‑p ADTSWRRtNsDsALH
3 18 S151‑p TSWRRtNsDsALHQs
0 1 S153‑p WRRtNsDsALHQsTM
0 2 S158‑p sDsALHQsTMtPTQP
0 2 T161‑p ALHQsTMtPTQPESF
0 1 T163 HQsTMtPTQPESFSS
1 0 S167 MtPTQPESFSSGsQD
0 5 S172‑p PESFSSGsQDVHQKR
0 1 S312‑p QHRPAGVsPLSLSTE
0 3 S330‑p QQASPTLsPLsPITQ
0 1 S333‑p SPTLsPLsPITQAVA
0 1 S424‑p VPSSLPQsPPENPGQ
0 1 P426 SSLPQsPPENPGQPS
0 1 P432 PPENPGQPSMGIDIA
3359 : Phospho-Torc1/Crtc1 (Ser151) Antibody
  TORC1 iso2  
K47 AARLQLQKSQYLQLG
S48 ARLQLQKSQYLQLGP
Y50 LQLQKSQYLQLGPSR
S64 RGQYYGGSLPNVNQI
S129 RERGRLGSPHRRPLS
S136 SPHRRPLSVDKHGRQ
K139 RRPLSVDKHGRQADS
S146 KHGRQADSCPYGTMY
Y149 RQADSCPYGTMYLSP
Y153 SCPYGTMYLSPPADT
S155 PYGTMYLSPPADTSW
T165 ADTSWRRTNSDSALH
S167 TSWRRTNSDSALHQS
S169 WRRTNSDSALHQSTM
S174 SDSALHQSTMTPTQP
T177 ALHQSTMTPTQPESF
T179 HQSTMTPTQPESFSS
S183 MTPTQPESFSSGSQD
S188 PESFSSGSQDVHQKR
S328 QHRPAGVSPLSLSTE
S346 QQASPTLSPLSPITQ
S349 SPTLSPLSPITQAVA
S440 VPSSLPQSPPENPGQ
P442 SSLPQSPPENPGQPS
P448 PPENPGQPSMGIDIA
  TORC1 iso3  
K47 AARLQLQKSQYLQLG
S48 ARLQLQKSQYLQLGP
Y50 LQLQKSQYLQLGPSR
S64 RGQYYGGSLPNVNQI
S113 RERGRLGSPHRRPLS
S120 SPHRRPLSVDKHGRQ
K123 RRPLSVDKHGRQADS
S130 KHGRQADSCPYGTMY
Y133 RQADSCPYGTMYLSP
Y137 SCPYGTMYLSPPADT
S139 PYGTMYLSPPADTSW
T149 ADTSWRRTNSDSALH
S151 TSWRRTNSDSALHQS
S153 WRRTNSDSALHQSTM
S158 SDSALHQSTMTPTQP
T161 ALHQSTMTPTQPESF
T163 HQSTMTPTQPESFSS
S167 MTPTQPESFSSGSQD
S172 PESFSSGSQDVHQKR
S312 QHRPAGVSPLSLSTE
S330 QQASPTLSPLSPITQ
S333 SPTLSPLSPITQAVA
S424 VPSSLPQSPPENPGQ
P426 SSLPQSPPENPGQPS
P432 PPENPGQPSMGIDIA
  mouse

 
K47 AARLQLQKSQYLQLG
S48 ARLQLQKSQYLQLGP
Y50 LQLQKSQYLQLGPSR
S64‑p RGQYYGGsLPNVNQI
S113‑p RERGRLGsPHRRPLs
S120‑p sPHRRPLsVDKHGRQ
K123 RRPLsVDKHGRQADS
S130 KHGRQADSCPyGTVy
Y133‑p RQADSCPyGTVyLsP
Y137‑p SCPyGTVyLsPPADT
S139‑p PyGTVyLsPPADTSW
T149 ADTSWRRTNsDSALH
S151‑p TSWRRTNsDSALHQS
S153 WRRTNsDSALHQSTM
S158 sDSALHQSTMTPsQA
T161 ALHQSTMTPsQAESF
S163‑p HQSTMTPsQAESFTG
S167 MTPsQAESFTGGsQD
S172‑p AESFTGGsQDAHQKR
S308 QHRPAVVSPLSLSTE
S329 QQVSPTLSPLSPITQ
S332 SPTLSPLSPITQAVA
S421 VPSTLPQSPtENPGQ
T423‑p STLPQSPtENPGQsP
S429‑p PtENPGQsPMGIDAT
3359 : Phospho-Torc1/Crtc1 (Ser151) Antibody
  rat

 
K47 AARLQLQKSQYLQLG
S48 ARLQLQKSQYLQLGP
Y50 LQLQKSQYLQLGPSR
S64 RGQYYGGSLPNVNQI
S113 RERGRLGSPHRRPLS
S120 SPHRRPLSVDKHGRQ
K123 RRPLSVDKHGRQADS
S130 KHGRQADSCPYGTVY
Y133 RQADSCPYGTVYLSP
Y137 SCPYGTVYLSPPADT
S139 PYGTVYLSPPADTSW
T149‑p ADTSWRRtNsDSALH
S151‑p TSWRRtNsDSALHQS
S153 WRRtNsDSALHQSTM
S158 sDSALHQSTMTPTQA
T161 ALHQSTMTPTQAEsF
T163 HQSTMTPTQAEsFTG
S167‑p MTPTQAEsFTGGPQD
P172 AEsFTGGPQDAHQKR
S308 QRRPAVVSPLSLSTE
S329 QQVPPTLSPLSPITQ
S332 PPTLSPLSPITQAVA
S421 VPSTLPQSPTESPGQ
T423 STLPQSPTESPGQPP
P429 PTESPGQPPMGIDVT
3359 : Phospho-Torc1/Crtc1 (Ser151) Antibody
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