a protein kinase of the STE20 family. Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. May play a role in hematopoietic lineage decisions and growth regulation. Positively regulated by PGE2 and a negative regulator of PGE2-induced FOS gene transcription. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, STE; EC 22.214.171.124; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; KHS subfamily
Molecular Function: ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: activation of JNK activity; activation of MAPKKK activity; cell proliferation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; response to stress
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.