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Protein Page:
HPK1 (human)

Overview
HPK1 a protein kinase of the STE20 family. Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. May play a role in hematopoietic lineage decisions and growth regulation. Positively regulated by PGE2 and a negative regulator of PGE2-induced FOS gene transcription. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, STE; STE group; STE20 family; KHS subfamily
Chromosomal Location of Human Ortholog: 19q13.1-q13.4
Cellular Component: cytoplasm; membrane
Molecular Function: ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: activation of JNK activity; activation of MAPKKK activity; cell proliferation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to stress
Reference #:  Q92918 (UniProtKB)
Alt. Names/Synonyms: Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK1; M4K1; MAP4K1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; Mitogen-activated protein kinase kinase kinase kinase 1
Gene Symbols: MAP4K1
Molecular weight: 91,296 Da
Basal Isoelectric point: 8.65  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HPK1

Protein Structure Not Found.
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Sites Implicated In
transcription, altered: T165‑p, S171‑p, T175‑p
enzymatic activity, induced: T165‑p, S171‑p, T175‑p
protein degradation: T165‑p, S171‑p, T175‑p
ubiquitination: T355‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 26 Y28‑p QRLGGGTyGEVFKAR
2 0 T165‑p ISAQIGAtLARRLsF
3 11 S171‑p AtLARRLsFIGtPyW
2 3 T175‑p RRLsFIGtPyWMAPE
0 1 Y177‑p LsFIGtPyWMAPEVA
0 1 S258‑p IKVTLTKsPKKRPSA
0 4 S320‑p AIPRRIRsTHRsssL
0 2 S324‑p RIRsTHRsssLGIPD
0 2 S325‑p IRsTHRsssLGIPDA
0 4 S326‑p RsTHRsssLGIPDAD
1 5 T349‑p RKLRGMEtRPPANtA
1 6 T355‑p EtRPPANtARLQPPR
0 3 S366‑p QPPRDLRsSsPRKQL
0 2 S367 PPRDLRsSsPRKQLs
0 2 S368‑p PRDLRsSsPRKQLsE
0 1 K371 LRsSsPRKQLsEssD
0 5 S374‑p SsPRKQLsEssDDDy
0 7 S376‑p PRKQLsEssDDDyDD
0 3 S377‑p RKQLsEssDDDyDDV
2 1 Y381‑p sEssDDDyDDVDIPT
0 10 S405‑p PPKPKFRsPsDEGPG
0 26 S407‑p KPKFRsPsDEGPGsM
0 17 S413‑p PsDEGPGsMGDDGQL
0 58 S421‑p MGDDGQLsPGVLVRC
0 25 S430‑p GVLVRCAsGPPPNsP
0 9 S436‑p AsGPPPNsPRPGPPP
0 2 S444‑p PRPGPPPsTssPHLt
0 1 S446‑p PGPPPsTssPHLtAH
0 4 S447‑p GPPPsTssPHLtAHs
0 5 T451‑p sTssPHLtAHsEPSL
0 8 S454‑p sPHLtAHsEPSLWNP
0 2 H561 SLSGKTPHLYSHSIL
0 1 Y563 SGKTPHLYSHSILGL
0 4 S586‑p GNPIAHIsPHRLLAR
0 1 S598‑p LARKNMVstKIQDTK
0 2 T599‑p ARKNMVstKIQDTKG
0 1 S737‑p KLVTPEGsPVRGLRT
  mouse

 
Y28 QRLGGGTYGEVFKAR
T165 ISAQIGATLARRLsF
S171‑p ATLARRLsFIGTPYW
T175 RRLsFIGTPYWMAPE
Y177 LsFIGTPYWMAPEVA
N258 VKVTLTKNSKKRPSA
S319 AIPRRIRSTYRASSL
A323 RIRSTYRASSLGIPD
S324 IRSTYRASSLGIPDA
S325 RSTYRASSLGIPDAD
C348 QRPRCVDCRPQAETV
T354 DCRPQAETVRLYPPA
S365‑p YPPAHFGstsPRsQL
T366‑p PPAHFGstsPRsQLs
S367‑p PAHFGstsPRsQLsD
S370‑p FGstsPRsQLsDsDD
S373‑p tsPRsQLsDsDDDyD
S375‑p PRsQLsDsDDDyDDV
- gap
Y379‑p LsDsDDDyDDVDIPA
S403 PPKPKFRSPsDDGSG
S405‑p KPKFRSPsDDGSGGI
G411 PsDDGSGGIRDDGQL
S419‑p IRDDGQLsPGVLVRC
S428 GVLVRCASGPPPRTP
T434 ASGPPPRTPRPGPPP
A442 PRPGPPPATCsPHLT
C444 PGPPPATCsPHLTAR
S445‑p GPPPATCsPHLTARs
T449 ATCsPHLTARsDPSL
S452‑p sPHLTARsDPSLWNP
Y567‑p SLSGKTPyLySHSIL
Y569‑p SGKTPyLySHSILGL
S592 GSPIAHISPHRLLAR
S604 LARKNMVSsKIQDTK
S605‑p ARKNMVSsKIQDTKG
A743 KLVTPEGAPAPGLRT
  rat

 
Y28 QRLGGGTYGEVFKAR
T165 ISAQIGATLARRLSF
S171 ATLARRLSFIGTPYW
T175 RRLSFIGTPYWMAPE
Y177 LSFIGTPYWMAPEVA
N258 VKVTLTKNSKKRPSA
S319 AIPRRIRSTYRASSL
A323 RIRSTYRASSLGIPD
S324 IRSTYRASSLGIPDA
S325 RSTYRASSLGIPDAD
C348 QRPRCVECRSQADTV
T354 ECRSQADTVLLQPSA
S365 QPSADFRSTSPRSQL
T366 PSADFRSTSPRSQLS
S367 SADFRSTSPRSQLSD
S370 FRSTSPRSQLSDSDD
S373 TSPRSQLSDSDDDYD
S375 PRSQLSDSDDDYDDV
- gap
Y379 LSDSDDDYDDVDIPA
S403 PPKPKIRSPSDDGSG
S405 KPKIRSPSDDGSGGV
G411 PSDDGSGGVRDDGQL
S419‑p VRDDGQLsPGVLVRC
S428 GVLVRCASGPPPRIP
I434 ASGPPPRIPRPGPPP
A442 PRPGPPPATRSPHLT
R444 PGPPPATRSPHLTAR
S445 GPPPATRSPHLTARs
T449 ATRSPHLTARsDPSL
S452‑p SPHLTARsDPSLWNP
H567 SLSGKTPHLYSHSIL
Y569 SGKTPHLYSHSILGL
S592 GSPIAHISPHRFLAR
S604 LARKNMVSSKIQDTK
S605 ARKNMVSSKIQDTKG
A743 KLVTPEGAPAPGLRT
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