Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
EGR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EGR1 Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. By growth factors. Belongs to the EGR C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; C2H2-type zinc finger protein; Transcription factor
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: DNA binding; histone acetyltransferase binding; metal ion binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: BMP signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of protein sumoylation; response to glucose stimulus; response to insulin stimulus; T cell differentiation; transcription from RNA polymerase II promoter
Reference #:  P18146 (UniProtKB)
Alt. Names/Synonyms: AT225; early growth response 1; Early growth response protein 1; EGR-1; EGR1; G0S30; KROX-24; KROX24; Nerve growth factor-induced protein A; NGFI-A; TIS8; Transcription factor ETR103; Transcription factor Zif268; ZIF-268; Zinc finger protein 225; Zinc finger protein Krox-24; ZNF225
Gene Symbols: EGR1
Molecular weight: 57,507 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EGR1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
transcription, altered: S104‑p, T148‑p, S196‑p, S301‑p, S378‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S12‑p KAEMQLMsPLQISDP
0 7 S26‑p PFGSFPHsPTMDNYP
1 0 S104‑p YEHLTAEsFPDISLN
0 2 S120‑gl EKVLVETsYPSQTTR
1 0 T148‑p PAPNSGNtLWPEPLF
1 0 S196‑p PLSCAVPsNDSSPIY
1 0 S301‑p AFATQSGsQDLKALN
1 0 S378‑p RICMRNFsRSDHLTT
  mouse

 
S12 KAEMQLMSPLQISDP
S26 PFGSFPHSPTMDNYP
S101 YEHLTTESFSDIALN
S117‑gl EKAMVETsYPSQTTR
T145 PAPNSGNTLWPEPLF
S194 PLSCAVPSNDSSPIY
S299 AFATQSGSQDLKALN
S376 RICMRNFSRSDHLTT
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.