a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Cell cycle regulation; Activator
Molecular Function: androgen receptor binding; cyclin-dependent protein kinase regulator activity; kinase activity; protein binding; protein complex binding; protein kinase binding; transcription coactivator activity
Biological Process: androgen receptor signaling pathway; antral ovarian follicle growth; cell division; cellular response to nutrient; DNA replication initiation; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; liver development; organ regeneration; positive regulation of cell differentiation; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of cell cycle; regulation of protein kinase activity; response to corticosterone stimulus; response to cytokine stimulus; response to drug; response to estradiol stimulus; response to ethanol; response to methylmercury; response to progesterone stimulus; response to purine; response to vitamin E; Wnt receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.