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Protein Page:
CCNE1 (human)

Overview
CCNE1 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Activator; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 19q12
Cellular Component: cytosol; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; protein amino acid phosphorylation
Reference #:  P24864 (UniProtKB)
Alt. Names/Synonyms: CCNE; CCNE1; cyclin E1; cyclin Es; cyclin Et; G1/S-specific cyclin-E1
Gene Symbols: CCNE1
Molecular weight: 47,077 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CCNE1

Protein Structure Not Found.
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Sites Implicated In
cell cycle regulation: T395‑p
intracellular localization: S399‑p
molecular association, regulation: T77‑p, T395‑p, S399‑p
protein degradation: T77‑p, S387‑p, T395‑p, S399‑p
ubiquitination: T395‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S59‑p TARDQCGsQPWDNNA
1 0 S73‑p AVCADPCsLIPtPDK
7 1 T77‑p DPCsLIPtPDKEDDD
1 0 S90‑p DDRVYPNsTCKPRII
1 10 S103‑p IIAPSRGsPLPVLSW
0 2 S381‑p RAKKAMLsEQNRAsP
2 14 S387‑p LsEQNRAsPLPSGLL
14 9 T395‑p PLPSGLLtPPQsGKK
4 3 S399‑p GLLtPPQsGKKQSSG
4136 : Phospho-Cyclin E (Thr62) Antibody
  mouse

 
S56 TVKSEDSSQPWDDNS
S70 SACVDPCSFIPtPNK
T74‑p DPCSFIPtPNKEEDN
T88 NELEYPRTAFQPRKI
S101‑p KIRPPRAsPLPVLNW
S379 QAKKAILSEQNRIsP
S385‑p LSEQNRIsPPPSVVL
T393‑p PPPSVVLtPPPSSKK
S397 VVLtPPPSSKKQSSE
  rat

 
S59 TVKSQDSSQPWDDDS
S73 SACVDPCSFIPTPNK
T77 DPCSFIPTPNKEEDN
T91 NELEYPKTAFQPRKI
S104 KIRPPRASPLPVLNW
S382 QAKKAILSEQNRISP
S388 LSEQNRISPPPSGVL
T396 PPPSGVLTPPHSSKK
S400 GVLTPPHSSKKQSSE
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