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Protein Page:
CCNE1 (human)

Overview
CCNE1 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Cell cycle regulation; Activator
Chromosomal Location of Human Ortholog: 19q12
Cellular Component: centrosome; cyclin-dependent protein kinase holoenzyme complex; cytosol; nucleoplasm; nucleus
Molecular Function: androgen receptor binding; cyclin-dependent protein kinase regulator activity; kinase activity; protein binding; protein complex binding; protein kinase binding; transcription coactivator activity
Biological Process: androgen receptor signaling pathway; antral ovarian follicle growth; cell division; cellular response to nutrient; DNA replication initiation; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; liver development; organ regeneration; positive regulation of cell differentiation; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of cell cycle; regulation of protein kinase activity; response to corticosterone stimulus; response to cytokine stimulus; response to drug; response to estradiol stimulus; response to ethanol; response to methylmercury; response to progesterone stimulus; response to purine; response to vitamin E; Wnt receptor signaling pathway
Reference #:  P24864 (UniProtKB)
Gene Symbols: CCNE1
Molecular weight: 47,077 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Select Structure to View Below

CCNE1

Protein Structure Not Found.
Download PyMol Script
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Sites Implicated In
cell cycle regulation: T395‑p
intracellular localization: S399‑p
molecular association, regulation: T77‑p, T395‑p, S399‑p
protein degradation: T77‑p, S387‑p, T395‑p, S399‑p
ubiquitination: T395‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S59‑p TARDQCGsQPWDNNA
1 0 S73‑p AVCADPCsLIPtPDK
7 1 T77‑p DPCsLIPtPDKEDDD
1 0 S90‑p DDRVYPNsTCKPRII
1 10 S103‑p IIAPSRGsPLPVLSW
0 2 S381‑p RAKKAMLsEQNRAsP
2 14 S387‑p LsEQNRAsPLPSGLL
14 9 T395‑p PLPSGLLtPPQsGKK
4 3 S399‑p GLLtPPQsGKKQSSG
4136 : Phospho-Cyclin E (Thr62) Antibody
  mouse

 
S56 TVKSEDSSQPWDDNS
S70 SACVDPCSFIPtPNK
T74‑p DPCSFIPtPNKEEDN
T88 NELEYPRTAFQPRKI
S101‑p KIRPPRAsPLPVLNW
S379 QAKKAILSEQNRIsP
S385‑p LSEQNRIsPPPSVVL
T393‑p PPPSVVLtPPPSSKK
S397 VVLtPPPSSKKQSSE
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