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Protein Page:
CCND1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CCND1 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Activator; Cell cycle regulation; Oncoprotein
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: cyclin-dependent protein kinase holoenzyme complex; cytosol; intracellular; membrane; nucleoplasm; nucleus; tight junction; transcriptional repressor complex
Molecular Function: cyclin-dependent protein kinase regulator activity; enzyme binding; histone deacetylase binding; protein binding; protein complex binding; protein kinase activity; protein kinase binding; transcription corepressor activity; transcription factor binding
Biological Process: cell division; establishment and/or maintenance of chromatin architecture; fat cell differentiation; G1 DNA damage checkpoint; G1/S transition of mitotic cell cycle; lactation; Leydig cell differentiation; liver development; mammary gland epithelial cell proliferation; mitotic cell cycle; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of Wnt receptor signaling pathway; Notch signaling pathway; organ regeneration; positive regulation of cyclin-dependent protein kinase activity; positive regulation of mammary gland epithelial cell proliferation; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; re-entry into mitotic cell cycle; response to calcium ion; response to corticosterone stimulus; response to DNA damage stimulus; response to drug; response to estradiol stimulus; response to ethanol; response to iron ion; response to magnesium ion; response to organic nitrogen; response to vitamin E; response to X-ray; transcription, DNA-dependent; unfolded protein response; Wnt receptor signaling pathway through beta-catenin
Disease: Myeloma, Multiple; Von Hippel-lindau Syndrome
Reference #:  P24385 (UniProtKB)
Alt. Names/Synonyms: B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; BCL1; CCND1; CycD1; cyclin D1; D11S287E; G1/S-specific cyclin D1; G1/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31
Gene Symbols: CCND1
Molecular weight: 33,729 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCND1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: T286‑p
cell growth, altered: T286‑p
intracellular localization: T286‑p, T288‑p
molecular association, regulation: T286‑p
protein degradation: T286‑p, T288‑p
ubiquitination: T286‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 K33‑ub RVLRAMLkAEETCAP
0 11 K46‑ub APSVSYFkCVQkEVL
0 2 K50‑ub SYFkCVQkEVLPSMR
1 0 S90‑p NYLDRFLsLEPVkkS
0 4 K95‑ub FLsLEPVkkSRLQLL
0 1 K96‑ub LsLEPVkkSRLQLLG
0 1 S111‑p ATCMFVAsKMkETIP
0 1 K114‑ub MFVAsKMkETIPLTA
0 1 S131‑p LCIYTDNsIRPEELL
0 1 K167‑ub FIEHFLSkMPEAEEN
0 5 K175‑ub MPEAEENkQIIRKHA
1 0 S197‑p ATDVKFIsNPPSMVA
0 1 S219‑p VQGLNLRsPNNFLSy
0 1 Y226‑p sPNNFLSyYRLTRFL
1 0 S234‑p YRLTRFLsRVIkCDP
0 8 K238‑ub RFLsRVIkCDPDCLR
1 0 K269‑ub AQQNMDPkAAEEEEE
26 5 T286‑p EEVDLACtPtDVRDV
5 0 T288‑p VDLACtPtDVRDVDI
3300 : Phospho-Cyclin D1 (Thr286) (D29B3) XP(R) Rabbit mAb
8497 : Phospho-Cyclin D1 (Thr286) (D29B3) XP(R) Rabbit mAb (PE Conjugate)
  mouse

 
K33 RVLRAMLKTEETCAP
K46‑ub APSVSYFkCVQKEIV
K50 SYFkCVQKEIVPSMR
S90 NYLDRFLSLEPLKKS
K95 FLSLEPLKKSRLQLL
K96 LSLEPLKKSRLQLLG
S111 ATCMFVASKMKETIP
K114 MFVASKMKETIPLTA
S131 LCIYTDNSIRPEELL
K167 FIEHFLSKMPEADEN
K175 MPEADENKQTIRKHA
S197 ATDVKFISNPPSMVA
S219 MQGLNLGSPNNFLSC
C226 SPNNFLSCYRTTHFL
S234 YRTTHFLSRVIkCDP
K238‑ub HFLSRVIkCDPDCLR
K269 AQQNVDPKATEEEGE
T286‑p EEAGLACtPtDVRDV
T288‑p AGLACtPtDVRDVDI
  rat

 
K33 RVLRAMLKTEETCAP
K46 APSVSYFKCVQREIV
R50 SYFKCVQREIVPSMR
S90 NYLDRFLSLEPLKKS
K95 FLSLEPLKKSRLQLL
K96 LSLEPLKKSRLQLLG
S111 ATCMFVASKMKETIP
K114 MFVASKMKETIPLTA
S131 LCIYTDNSIRPEELL
K167 FIEHFLSKMPEADEN
K175 MPEADENKQIIRKHA
S197 ATDVKFISNPPSMVA
S219 MQGLNLGSPNNFLSC
C226 SPNNFLSCYRTTHFL
S234 YRTTHFLSRVIKCDP
K238 HFLSRVIKCDPDCLR
K269 AQQNIDPKATEEEGE
T286 EEAGLACTPTDVRDV
T288 AGLACTPTDVRDVDI
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