a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Complexes with cdc2 to form the maturation-promoting factor (MPF). Two alternatively spliced isoforms have been found, a constitutively expressed form and a cell cycle-regulated form that is expressed predominantly during G2/M phase. Note: This description may include information from UniProtKB.
Cellular Component: centrosome; cytoplasm; cytosol; nucleoplasm; nucleus; spindle pole
Molecular Function: cyclin-dependent protein kinase activity; patched binding; protein binding; protein kinase binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G2/M transition of mitotic cell cycle; mitotic metaphase plate congression; mitotic nuclear envelope disassembly; mitotic spindle organization and biogenesis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.