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Protein Page:
CIITA (human)

CIITA a non-DNA binding transactivator that functions both in constitutive and inducible MHC Class II expression. Defects are a cause of bare lymphocyte syndrome type II (BLS II), a form of severe combined immunodeficiency disease (SCID) characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, an absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 16p13
Cellular Component: nucleoplasm; PML body
Molecular Function: DNA binding; protein binding; protein C-terminus binding; protein complex binding; transcription activator binding; transcription coactivator activity
Biological Process: immune response; negative regulation of collagen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of MHC class I biosynthetic process; positive regulation of MHC class II biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to antibiotic
Disease: Bare Lymphocyte Syndrome, Type Ii; Rheumatoid Arthritis
Reference #:  P33076 (UniProtKB)
Alt. Names/Synonyms: C2TA; CIITA; CIITAIV; class II transactivator; class II, major histocompatibility complex, transactivator; MHC class II transactivator; MHC class II transactivator type III; MHC2TA; NLR family, acid domain containing; NLRA; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
Gene Symbols: CIITA
Molecular weight: 123,514 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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