a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-alpha, -delta and -gamma. Involved in immune and inflammatory responses. Specifically binds to regulatory regions of genes encoding IL-6, other cytokines and several acute-phase proteins. There are two forms of C/EBPbeta, the 38kDa liver activating protein (LAP) and the 20kDa liver inhibitory protein (LIP) which may be products of alternative translation. LAP is a transcriptional activator while LIP may inhibit C/EBPbeta transcriptional activity. Phosphorylated and activated by ERK1/2. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA-binding; Motility/polarity/chemotaxis
Molecular Function: DNA binding; protein binding; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding
Biological Process: acute-phase response; defense response to bacterium; immune response; inflammatory response; negative regulation of T cell proliferation; ovarian follicle development; positive regulation of fat cell differentiation; positive regulation of interleukin-4 production; positive regulation of transcription from RNA polymerase II promoter; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.