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Protein Page:
CTCF (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CTCF a widely expressed, sequence-specific DNA-binding transcriptional regulator, insulator, and organizer of higher-order chromatin structure. Acts as a tumor suppressor. Contains 11 C2H2-type zinc fingers. Involved in promoter activation or repression, hormone-responsive gene silencing, methylation-dependent chromatin insulation, and genomic imprinting. Mediates pairing between X chromosomes and interactions between distant regulatory elements. Binds to promoters of c-myc, PLK, PIM1 and APP. A critical regulator of cell-cycle arrest and death after B cell receptor signaling in immature B cells. CTCF, together with YY1 and Tsix, form a regulated epigenetic switch for X-inactivation. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Tumor suppressor; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 16q21-q22.3
Cellular Component: chromosome, pericentric region; condensed chromosome; nucleolus; nucleoplasm; nucleus
Molecular Function: chromatin insulator sequence binding; protein binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity; zinc ion binding
Biological Process: chromatin modification; chromosome segregation; DNA methylation; genetic imprinting; maintenance of DNA methylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleosome positioning; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gene expression, epigenetic; regulation of histone acetylation; regulation of histone methylation; regulation of molecular function, epigenetic; transcription from RNA polymerase II promoter
Disease: Mental Retardation, Autosomal Dominant 21
Reference #:  P49711 (UniProtKB)
Alt. Names/Synonyms: 11 zinc finger transcriptional repressor; 11-zinc finger protein; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein); CTCF; CTCFL paralog; Transcriptional repressor CTCF
Gene Symbols: CTCF
Molecular weight: 82,785 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CTCF

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 K20‑ac SETFIKGkERKTYQR
0 1 T45 CHLPQNQTDGGEVVQ
2 0 K74‑sm DPTLLQMkTEVMEGT
0 7 Y197‑p SWQKDPDyQPPAKKT
0 1 S224‑p EGKDVDVsVyDFEEE
0 1 Y226‑p KDVDVsVyDFEEEQQ
0 1 S279 SYTCPRRSNLDRHMK
0 2 T289‑p DRHMKSHtDERPHKC
0 1 T305‑p LCGRAFRtVtLLRNH
0 1 T307‑p GRAFRtVtLLRNHLN
0 3 T317‑p RNHLNTHtGtRPHKC
0 2 T319‑p HLNTHtGtRPHKCPD
0 1 Y343 ELVRHRRYKHtHEKP
0 2 T346‑p RHRRYKHtHEKPFKC
0 9 T374‑p KRHIRSHtGERPFQC
0 1 S382‑p GERPFQCsLCSYASR
0 1 T400‑p KLKRHMRtHsGEKPy
0 6 S402‑p KRHMRtHsGEKPyEC
0 1 Y407‑p tHsGEKPyECyICHA
0 1 Y410‑p GEKPyECyICHARFT
0 1 T431‑p MHILQKHtENVAKFH
0 7 S450‑p DTVIARKsDLGVHLR
0 1 S461‑p VHLRKQHsyIEQGKK
0 2 Y462‑p HLRKQHsyIEQGKKC
0 4 T518‑p IMHKRTHtGEKPYAC
0 1 K543‑ub QLLDMHFkRyHDPNF
0 1 Y545‑p LDMHFkRyHDPNFVP
0 1 S558‑p VPAAFVCsKCGKTFT
0 1 T563 VCsKCGKTFTRRNTM
0 1 T565 sKCGKTFTRRNTMAR
0 1 T569 KTFTRRNTMARHADN
1 1 S604‑p GRKRKMRsKKEDssD
1 5 S609‑p MRsKKEDssDsENAE
1 6 S610‑p RsKKEDssDsENAEP
2 5 S612‑p KKEDssDsENAEPDL
0 1 T642‑p EPEPQPVtPAPPPAK
2 0 K689‑sm ENIIVEVkKEPDAEP
0 1 T709‑p EEAQPAAtDAPNGDL
0 11 T717‑p DAPNGDLtPEMILsM
0 2 S723‑p LtPEMILsMMDR___
  mouse

 
K20‑ac SETFIKGkERKTYQR
T45‑p CHLPQNQtDGGEVVQ
K74‑sm DPTLLQMkTEVMEGT
Y197 SWQKDPDYQPPAKKT
S224 EGKDVDVSVYDFEEE
Y226 KDVDVSVYDFEEEQQ
S279‑p SYTCPRRsNLDRHMK
T289 DRHMKSHTDERPHKC
T305 LCGRAFRTVTLLRNH
T307 GRAFRTVTLLRNHLN
T317 RNHLNTHTGTRPHKC
T319 HLNTHTGTRPHKCPD
Y343‑p ELVRHRRyKHTHEKP
T346 RHRRyKHTHEKPFKC
T374 KRHIRSHTGERPFQC
S382 GERPFQCSLCSYASR
T400 KLKRHMRTHsGEKPY
S402‑p KRHMRTHsGEKPYEC
Y407 THsGEKPYECYICHA
Y410 GEKPYECYICHARFT
T431 MHILQKHTENVAKFH
S450‑p DTVIARKsDLGVHLR
S461 VHLRKQHSYIEQGKK
Y462 HLRKQHSYIEQGKKC
T518 IMHKRTHTGEKPYAC
K543 QLLDMHFKRYHDPNF
Y545 LDMHFKRYHDPNFVP
S558 VPAAFVCSKCGKtFt
T563‑p VCSKCGKtFtRRNtM
T565‑p SKCGKtFtRRNtMAR
T569‑p KtFtRRNtMARHADN
S604 GRKRKMRSKKEDSSD
S609 MRSKKEDSSDSEENA
S610 RSKKEDSSDSEENAE
S612 KKEDSSDSEENAEPD
A651 PPPPQPVAPAPPPAK
K698‑sm ENIIVEVkKEPDAEP
T718 EEAQAATTDAPNGDL
T726 DAPNGDLTPEMILSM
S732 LTPEMILSMMDR___
  rat

 
K20 SETFIKGKERKTYQR
T45 CHLPQNQTDGGEVVQ
K74 DPTLLQMKTEVMEGT
Y197 SWQKDPDYQPPAKKT
S224 EGKDVDVSVYDFEEE
Y226 KDVDVSVYDFEEEQQ
S279 SYTCPRRSNLDRHMK
T289 DRHMKSHTDERPHKC
T305 LCGRAFRTVTLLRNH
T307 GRAFRTVTLLRNHLN
T317 RNHLNTHTGTRPHKC
T319 HLNTHTGTRPHKCPD
Y343 ELVRHRRYKHTHEKP
T346 RHRRYKHTHEKPFKC
T374 KRHIRSHTGERPFQC
S382 GERPFQCSLCSYASR
T400 KLKRHMRTHSGEKPY
S402 KRHMRTHSGEKPYEC
Y407 THSGEKPYECYICHA
Y410 GEKPYECYICHARFT
T431 MHILQKHTENVAKFH
S450 DTVIARKSDLGVHLR
S461 VHLRKQHSYIEQGKK
Y462 HLRKQHSYIEQGKKC
T518 IMHKRTHTGEKPYAC
K543 QLLDMHFKRYHDPNF
Y545 LDMHFKRYHDPNFVP
S558 VPAAFVCSKCGKTFT
T563 VCSKCGKTFTRRNTM
T565 SKCGKTFTRRNTMAR
T569 KTFTRRNTMARHADN
S604 GRKRKMRSKKEDSSD
S609 MRSKKEDSSDSENAE
S610 RSKKEDSSDSENAEP
S612 KKEDSSDSENAEPDL
A652 QPQPQPVAPAPPPAK
K699 ENIIVEVKKEPDAEP
A719 EEAQAAPADAPNGDL
T727‑p DAPNGDLtPEMILSM
S733 LtPEMILSMMDR___
  chicken

 
K20 SETFIKGKERKTYQR
A45 CHIAPNQADGGEVVQ
K74 DPTLLQMKTEVMEGA
Y197 NWQKDPDYQPPAKKT
S224 EGKDVDVSVYDFEEE
Y226 KDVDVSVYDFEEEQQ
S279 SYTCPRRSNLDRHMK
T289 DRHMKSHTDERPHKC
T305 LCGRAFRTVTLLRNH
T307 GRAFRTVTLLRNHLN
T317 RNHLNTHTGTRPHKC
T319 HLNTHTGTRPHKCPD
Y343 ELVRHRRYKHTHEKP
T346 RHRRYKHTHEKPFKC
T374 KRHIRSHTGERPFQC
S382 GERPFQCSLCSYASR
T400 KLKRHMRTHSGEKPY
S402 KRHMRTHSGEKPYEC
Y407 THSGEKPYECYICHA
Y410 GEKPYECYICHARFT
T431 MHILQKHTENVAKFH
S450 DTVIARKSDLGVHLR
S461 VHLRKQHSYIEQGKK
Y462 HLRKQHSYIEQGKKC
T518 VMHKRTHTGEKPYAC
K543 QLLDMHFKRYHDPNF
Y545 LDMHFKRYHDPNFVP
S558 VPAAFVCSKCGKTFT
T563 VCSKCGKTFTRRNTM
T565 SKCGKTFTRRNTMAR
T569 KTFTRRNTMARHADN
S604‑p GRKRKMRsKKEDssD
S609‑p MRsKKEDssDsEENA
S610‑p RsKKEDssDsEENAE
S612‑p KKEDssDsEENAEPD
A643 EPEVSAEAPAPPPSK
K691 ENIIVEVKKEPDAET
V710 EEAQPAVVEAPNGDL
T718 EAPNGDLTPEMILSM
S724 LTPEMILSMMDR___
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