a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric, Rho; Motility/polarity/chemotaxis; G protein; Tumor suppressor; G protein, monomeric
Cellular Component: cleavage furrow; cytosol; early endosome; endosome membrane; focal adhesion; late endosome membrane; nucleus; plasma membrane
Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding
Biological Process: angiogenesis; apoptosis; axon guidance; blood coagulation; cell adhesion; cytokinesis; endosome to lysosome transport; intracellular protein transport; negative regulation of cell cycle; negative regulation of cell migration; platelet activation; positive regulation of angiogenesis; positive regulation of apoptosis; regulation of cell migration; regulation of small GTPase mediated signal transduction; Rho protein signal transduction; small GTPase mediated signal transduction; transformed cell apoptosis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.