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Protein Page:
RHOB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RHOB a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis; G protein, monomeric; Tumor suppressor
Chromosomal Location of Human Ortholog: 2p24
Cellular Component: cleavage furrow; cytosol; endosome membrane; focal adhesion; nucleus; plasma membrane
Molecular Function: GTP binding; GTPase activity; protein binding
Biological Process: apoptosis; cell adhesion; cytokinesis; endosome to lysosome transport; negative regulation of cell cycle; negative regulation of cell migration; platelet activation; positive regulation of angiogenesis; positive regulation of apoptosis; regulation of cell migration; regulation of small GTPase mediated signal transduction; Rho protein signal transduction
Reference #:  P62745 (UniProtKB)
Alt. Names/Synonyms: Aplysia RAS-related homolog 6; ARH6; ARHB; h6; MST081; MSTP081; oncogene RHO H6; ras homolog gene family, member B; Rho cDNA clone 6; Rho-related GTP-binding protein RhoB; RHOB; RHOH6
Gene Symbols: RHOB
Molecular weight: 22,123 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RHOB

Protein Structure Not Found.
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Sites Implicated In
cytoskeletal reorganization: S185‑p
activity, inhibited: S185‑p
molecular association, regulation: S185‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 Y34‑p KDEFPEVyVPTVFEN
0 10 Y66‑p DTAGQEDyDRLRPLS
0 5 K118‑ub PIILVANkKDLRSDE
0 1 T129‑p RSDEHVRtELARMkQ
0 18 K135‑ub RtELARMkQEPVRTD
0 1 T141 MkQEPVRTDDGRAMA
0 10 Y154 MAVRIQAYDYLECSA
0 1 K162 DYLECSAKTKEGVRE
1 0 S185‑p ALQKRYGsQNGCINC
  mouse

 
Y34 KDEFPEVYVPTVFEN
Y66 DTAGQEDYDRLRPLS
K118‑ub PIILVANkKDLRSDE
T129 RSDEHVRTELARMkQ
K135‑ub RTELARMkQEPVRtD
T141‑p MkQEPVRtDDGRAMA
Y154‑p MAVRIQAyDYLECSA
K162‑ub DYLECSAkTKEGVRE
S185 ALQKRYGSQNGCINC
  rat

 
Y34 KDEFPEVYVPTVFEN
Y66 DTAGQEDYDRLRPLS
K118 PIILVANKKDLRSDE
T129 RSDEHVRTELARMkQ
K135‑ub RTELARMkQEPVRTD
T141 MkQEPVRTDDGRAMA
Y154‑p MAVRIQAyDYLECSA
K162 DYLECSAKTKEGVRE
S185 ALQKRYGSQNGCINC
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