a protein kinase of the STE20 family that regulates cell motility and morphology. Critical RhoGTPase effector that regulates cytoskeleton reorganization, the JNK MAPK pathway, and nuclear signaling. Binding of Rac/cdc42 to the PBD of PAK1 causes autophosphorylation and conformational change. Phosphorylated and activated by PDK. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); EC 22.214.171.124; Kinase, protein; STE group; STE20 family; PAKA subfamily
Molecular Function: collagen binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: actin cytoskeleton organization and biogenesis; actin cytoskeleton reorganization; amygdala development; axonogenesis; branching morphogenesis of a tube; cellular response to insulin stimulus; dendrite development; neurite morphogenesis; neuromuscular junction development; positive regulation of cell migration; positive regulation of estrogen receptor signaling pathway; positive regulation of JNK activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of stress fiber formation; protein amino acid autophosphorylation; protein amino acid phosphorylation; receptor clustering; regulation of actin cytoskeleton organization and biogenesis; regulation of gene expression; regulation of MAPKKK cascade; response to hypoxia; response to organic substance; wound healing
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.