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Protein Page:
HDAC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HDAC1 a transcriptional regulator of the histone deacetylase family, subfamily 1. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Note: This description may include information from UniProtKB.
Protein type: EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1p34
Cellular Component: chromatin; cytoplasm; cytosol; histone deacetylase complex; nuclear chromatin; nucleoplasm; nucleus; NuRD complex; protein complex; Sin3 complex
Molecular Function: deacetylase activity; enzyme binding; histone deacetylase activity; histone deacetylase binding; NF-kappaB binding; nucleosomal DNA binding; protein binding; protein deacetylase activity; protein N-terminus binding; transcription activator binding; transcription factor activity; transcription factor binding
Biological Process: ATP-dependent chromatin remodeling; blood coagulation; chromatin modification; chromatin remodeling; circadian regulation of gene expression; embryonic digit morphogenesis; epidermal cell differentiation; histone deacetylation; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; odontogenesis of dentine-containing teeth; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid deacetylation
Reference #:  Q13547 (UniProtKB)
Alt. Names/Synonyms: DKFZp686H12203; GON-10; HD1; HDAC1; Histone deacetylase 1; reduced potassium dependency, yeast homolog-like 1; RPD3; RPD3L1
Gene Symbols: HDAC1
Molecular weight: 55,103 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HDAC1

Protein Structure Not Found.
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Sites Implicated In
enzymatic activity, induced: S421‑p, S423‑p
molecular association, regulation: S421‑p, S423‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T7 _MAQTQGTRRkVCYY
0 1 K10‑ub QTQGTRRkVCYYYDG
0 1 K58‑ub MEIYRPHkANAEEMT
0 5 K66‑ub ANAEEMTkYHSDDyI
0 1 Y72‑p TkYHSDDyIkFLRSI
0 2 K74‑ac YHSDDyIkFLRSIRP
1 7 K74‑ub YHSDDyIkFLRSIRP
0 9 Y87‑p RPDNMSEyskQMQRF
0 1 S88‑p PDNMSEyskQMQRFN
0 3 K89‑ac DNMSEyskQMQRFNV
0 77 K89‑ub DNMSEyskQMQRFNV
0 5 K126‑ub ASAVKLNkQQTDIAV
0 2 Y204‑p SFHKYGEyFPGTGDL
1 0 K218‑ac LRDIGAGkGkyYAVN
1 3 K220‑ac DIGAGkGkyYAVNyP
0 1 K220‑ub DIGAGkGkyYAVNyP
0 5 Y221‑p IGAGkGkyYAVNyPL
0 1 Y226‑p GkyYAVNyPLRDGID
0 2 K242‑ub ESYEAIFkPVMSKVM
0 1 K283‑ub LTIKGHAkCVEFVKs
0 1 S290‑p kCVEFVKsFNLPMLM
0 1 Y358‑p TNQNTNEyLEkIkQR
0 5 K361‑ub NTNEyLEkIkQRLFE
0 2 K363‑ub NEyLEkIkQRLFENL
1 331 S393‑p EDAIPEEsGDEDEDD
1 4 S406‑p DDPDKRIsICssDkR
0 8 S409‑p DKRIsICssDkRIAC
0 5 S410‑p KRIsICssDkRIACE
0 29 K412‑ac IsICssDkRIACEEE
0 1 K412 IsICssDKRIACEEE
2 95 S421‑p IACEEEFsDsEEEGE
1 92 S423‑p CEEEFsDsEEEGEGG
2 0 K432‑ac EEGEGGRkNssNFkk
0 1 K432‑me EEGEGGRkNssNFkk
0 6 S434‑p GEGGRkNssNFkkAk
0 1 S435‑p EGGRkNssNFkkAkR
1 0 K438‑ac RkNssNFkkAkRVkt
1 0 K439‑ac kNssNFkkAkRVktE
1 0 K441‑ac ssNFkkAkRVktEDE
2 1 K444‑sm FkkAkRVktEDEKEK
0 3 T445‑p kkAkRVktEDEKEKD
0 1 K457‑sm EKDPEEKkEVTEEEK
0 1 K476 KPEAKGVKEEVkLA_
2 1 K476‑sm KPEAKGVkEEVkLA_
0 1 K480‑ub KGVkEEVkLA_____
  mouse

 
T7‑p _MAQTQGtKRKVCYY
K10 QTQGtKRKVCYYYDG
K58 MEIYRPHKANAEEMT
K66 ANAEEMTKYHSDDYI
Y72 TKYHSDDYIkFLRSI
K74 YHSDDYIKFLRSIRP
K74‑ub YHSDDYIkFLRSIRP
Y87‑p RPDNMSEySkQMQRF
S88 PDNMSEySkQMQRFN
K89 DNMSEySKQMQRFNV
K89‑ub DNMSEySkQMQRFNV
K126 ASAVKLNKQQTDIAV
Y204 SFHKYGEYFPGTGDL
K218 LRDIGAGKGKyYAVN
K220 DIGAGKGKyYAVNYP
K220 DIGAGKGKyYAVNYP
Y221‑p IGAGKGKyYAVNYPL
Y226 GKyYAVNYPLRDGID
K242 ESYEAIFKPVMSKVM
K283 LTIKGHAKCVEFVKS
S290 KCVEFVKSFNLPMLM
Y358 TNQNTNEYLEkIKQR
K361‑ub NTNEYLEkIKQRLFE
K363 NEYLEkIKQRLFENL
S393‑p EDAIPEEsGDEDEED
S406‑p EDPDKRIsICssDkR
S409‑p DKRIsICssDkRIAC
S410‑p KRIsICssDkRIACE
K412‑ac IsICssDkRIACEEE
K412‑ub IsICssDkRIACEEE
S421‑p IACEEEFsDsDEEGE
S423‑p CEEEFsDsDEEGEGG
K432‑ac EEGEGGRkNSSNFKK
K432 EEGEGGRKNSSNFKK
S434 GEGGRkNSSNFKKAK
S435 EGGRkNSSNFKKAKR
K438 RkNSSNFKKAKRVKt
K439 kNSSNFKKAKRVKtE
K441 SSNFKKAKRVKtEDE
K444 FKKAKRVKtEDEKEK
T445‑p KKAKRVKtEDEKEKD
K457 EKDPEEKKEVTEEEK
K476 KPEAKGVKEEVKLA_
K476 KPEAKGVKEEVKLA_
K480 KGVKEEVKLA_____
  rat

 
T7 _MAQTQGTKRKVCYY
K10 QTQGTKRKVCYYYDG
K58 MEIYRPHKANAEEMT
K66 ANAEEMTKYHSDDYI
Y72 TKYHSDDYIkFLRSI
K74‑ac YHSDDYIkFLRSIRP
K74 YHSDDYIKFLRSIRP
Y87 RPDNMSEYSkQMQRF
S88 PDNMSEYSkQMQRFN
K89‑ac DNMSEYSkQMQRFNV
K89 DNMSEYSKQMQRFNV
K126 ASAVKLNKQQTDIAV
Y204 SFHKYGEYFPGTGDL
K218 LRDIGAGKGKYYAVN
K220 DIGAGKGKYYAVNYP
K220 DIGAGKGKYYAVNYP
Y221 IGAGKGKYYAVNYPL
Y226 GKYYAVNYPLRDGID
K242 ESYEAIFKPVMSKVM
K283 LTIKGHAKCVEFVKS
S290 KCVEFVKSFNLPMLM
Y358 TNQNTNEYLEKIKQR
K361 NTNEYLEKIKQRLFE
K363 NEYLEKIKQRLFENL
S393‑p EDAIPEEsGDEDEED
S406 EDPDKRISICSsDKR
S409 DKRISICSsDKRIAC
S410‑p KRISICSsDKRIACE
K412 ISICSsDKRIACEEE
K412 ISICSsDKRIACEEE
S421‑p IACEEEFsDsDEEGE
S423‑p CEEEFsDsDEEGEGG
K432 EEGEGGRKNSSNFKK
K432 EEGEGGRKNSSNFKK
S434 GEGGRKNSSNFKKAK
S435 EGGRKNSSNFKKAKR
K438 RKNSSNFKKAKRVKT
K439 KNSSNFKKAKRVKTE
K441 SSNFKKAKRVKTEDE
K444 FKKAKRVKTEDEKEK
T445 KKAKRVKTEDEKEKD
K457 EKDPEEKKEVTEEEK
K476‑ac KPEAKGVkEEVKMA_
K476 KPEAKGVKEEVKMA_
K480 KGVkEEVKMA_____
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