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Protein Page:
FGR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGR a non-receptor tyrosine kinase of the Src family. Contains one SH2 and one SH3 domain. Beta 2 integrin signaling induces its c-Cbl-mediated ubiquitination in adherent neutrophils. An ortholog of v-fgr feline oncogene. Mildly amplified in hormone-resistant prostate cancer. Copy number either increased or decreased in other cancers. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Protein kinase, TK; Kinase, protein; Oncoprotein; Protein kinase, tyrosine (non-receptor); Mitochondrial; TK group; Src family
Chromosomal Location of Human Ortholog: 1p36.2-p36.1
Cellular Component: actin cytoskeleton; cytoskeleton; cytosol; extrinsic to internal side of plasma membrane; mitochondrial inner membrane; mitochondrial intermembrane space; plasma membrane
Molecular Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; phosphotyrosine binding; protein binding; protein kinase binding; protein-tyrosine kinase activity
Biological Process: cell differentiation; cell migration; defense response to Gram-positive bacterium; immune response-regulating cell surface receptor signaling pathway; innate immune response; integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of cell migration; positive regulation of cytokine secretion; positive regulation of mast cell degranulation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; regulation of cell shape; regulation of innate immune response; regulation of phagocytosis; regulation of protein kinase activity; response to virus; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P09769 (UniProtKB)
Gene Symbols: FGR
Molecular weight: 59,479 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FGR

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 A13 CKKLEPVATAkEDAG
0 2 K16‑ub LEPVATAkEDAGLEG
0 22 Y28‑p LEGDFRSyGAADHyG
0 107 Y34‑p SyGAADHyGPDPTKA
0 1 S45 PTKARPASSFAHIPN
0 1 I61 SNFSSQAINPGFLDS
0 3 N62 NFSSQAINPGFLDSG
0 10 Y86‑p VTLFIALyDYEARTE
0 8 G112 HILNNTEGDWWEARS
0 3 K177‑ub IRESETTkGAysLSI
0 293 Y180‑p SETTkGAysLSIRDW
0 10 S181‑p ETTkGAysLSIRDWD
0 2 M205 YKIRKLDMGGyyItt
0 304 Y208‑p RKLDMGGyyIttRVQ
0 85 Y209‑p KLDMGGyyIttRVQF
0 2 T211‑p DMGGyyIttRVQFNS
0 1 T212‑p MGGyyIttRVQFNSV
0 3 S218 ttRVQFNSVQELVQH
0 1 S261‑p DAWEISRssITLERR
0 2 S262‑p AWEISRssITLERRL
0 1 T292‑p STKVAVKtLKPGTMS
0 5 K301‑ub KPGTMSPkAFLEEAQ
1 202 Y412‑p RLIKDDEyNPCQGSK
0 1 T453‑p ILLTELItKGRIPyP
0 1 Y459‑p ItKGRIPyPGMNKRE
1 170 Y523‑p FTSAEPQyQPGDQT_
  mouse

 
S13‑p CKKLEPAsKEDVGLE
K14 KKLEPAsKEDVGLEG
Q26 LEGDFRSQTAEERYF
Y32 SQTAEERYFPDPTQG
S43‑p PTQGRTSsVFPQPts
T49‑p SsVFPQPtsPAFLNT
S50‑p sVFPQPtsPAFLNTG
Y74‑p VTIFVALyDYEARTG
Y100‑p HILNNTEyDWWEARS
K165‑ub IRESETTkGAysLSI
Y168‑p SETTkGAysLSIRDW
S169‑p ETTkGAysLSIRDWD
T193‑p YKIRKLDtGGyYITT
Y196‑p RKLDtGGyYITTRAQ
Y197 KLDtGGyYITTRAQF
T199 DtGGyYITTRAQFDs
T200 tGGyYITTRAQFDsI
S206‑p TTRAQFDsIQDLVRH
N249 DAWEIDRNsIALERR
S250‑p AWEIDRNsIALERRL
T280 STKVAVKTLKPGTMS
K289 KPGTMSPKAFLEEAQ
Y400‑p RLIEDNEyNPQQGTK
T441 ILLTELITKGRVPYP
Y447 ITKGRVPYPGMNNRE
Y511‑p FTSTEPQyQPGDQT_
  rat

 
P13 CKKLEPAPKEDVGLE
K14 KKLEPAPKEDVGLEG
Q26 LEGDFRSQGAEERYY
Y32 SQGAEERYYPDPTQG
S43 PTQGRSSSISPQPIs
- gap
S50‑p SISPQPIsPAFLNVG
Y74 VTIFVALYDYEARTG
Y100 HILNNTEYDWWEARS
K165 IRESETTKGAysLSI
Y168‑p SETTKGAysLSIRDW
S169‑p ETTKGAysLSIRDWD
M193 YKIRKLDMGGyyITT
Y196‑p RKLDMGGyyITTRAQ
Y197‑p KLDMGGyyITTRAQF
T199 DMGGyyITTRAQFES
T200 MGGyyITTRAQFESV
S206 TTRAQFESVQDLVRH
N249 DAWEIDRNSIALDRR
S250 AWEIDRNSIALDRRL
T280 STKVAVKTLKPGTMS
K289 KPGTMSPKAFLEEAQ
Y400‑p RLIVDDEyNPQQGTK
T441 ILLTELITKGRVPYP
Y447 ITKGRVPYPGMNNRE
Y511‑p FTSTEPQyQPGDQT_
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