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Protein Page:
LITAF (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LITAF Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression. Interacts with NEDD4. Interacts with WWOX. Isoform 2 may interact with STAT6. By bacterial lipopolysaccharides (LPS) or p53/TP53. In monocytes by the Bacillus Calmette-Guerin (BCG). Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Oncoprotein
Chromosomal Location of Human Ortholog: 16p13.13
Cellular Component: cytoplasm; Golgi apparatus; intracellular membrane-bound organelle; lysosomal membrane; nucleoplasm; plasma membrane
Molecular Function: protein binding; signal transducer activity; WW domain binding
Biological Process: aging; apoptosis; negative regulation of NF-kappaB import into nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of cytokine production; regulation of transcription from RNA polymerase II promoter; signal transduction; transcription, DNA-dependent
Disease: Charcot-marie-tooth Disease, Demyelinating, Type 1c
Reference #:  Q99732 (UniProtKB)
Alt. Names/Synonyms: FLJ38636; lipopolysaccharide-induced TNF factor; lipopolysaccharide-induced TNF-alpha factor; Lipopolysaccharide-induced tumor necrosis factor-alpha factor; LITAF; LPS-induced TNF-alpha factor; MGC116698; MGC116700; MGC116701; MGC125274; MGC125275; MGC125276; p53-induced gene 7 protein; PIG7; SIMPLE; Small integral membrane protein of lysosome/late endosome; TP53I7; tumor protein p53 inducible protein 7
Gene Symbols: LITAF
Molecular weight: 17,107 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LITAF

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 Y23‑p APSAPPSyEETVAVN
0 2 S31‑p EETVAVNsyyPTPPA
0 4 Y32‑p ETVAVNsyyPTPPAP
0 2 Y33‑p TVAVNsyyPTPPAPM
0 1 S60‑p GKGMNPPsyytQPAP
0 4 Y61‑p KGMNPPsyytQPAPI
0 7 Y62‑p GMNPPsyytQPAPIP
0 1 T63‑p MNPPsyytQPAPIPN
0 1 S105‑p SCNKMIVsQLSYNAG
0 1 - gap
0 1 - gap
0 3 K159‑ub RALLGTYkRL_____
  LITAF iso3  
Y23 APSAPPSYEETVAVN
S31 EETVAVNSYYPTPPA
Y32 ETVAVNSYYPTPPAP
Y33 TVAVNSYYPTPPAPM
S60 GKGMNPPSYYTQPAP
Y61 KGMNPPSYYTQPAPI
Y62 GMNPPSYYTQPAPIP
T63 MNPPSYYTQPAPIPN
S105 SCNKMIVSQLSYNAG
S138‑p GTIVALRsFDLLGsC
S144‑p RsFDLLGsCNPPSSA
- gap
  mouse

 
Y23 VPTAPPTYEETVGVN
S31 EETVGVNSYYPTPPA
Y32 ETVGVNSYYPTPPAP
Y33 TVGVNSYYPTPPAPM
S60 GKGMNPPSYYTQPVP
Y61 KGMNPPSYYTQPVPV
Y62 GMNPPSYYTQPVPVP
T63 MNPPSYYTQPVPVPN
T105 SCSKMIVTQLSYNAG
- gap
- gap
K159‑ub KALLGTYkRL_____
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