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Protein Page:
LITAF (human)

LITAF Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression. Interacts with NEDD4. Interacts with WWOX. Isoform 2 may interact with STAT6. By bacterial lipopolysaccharides (LPS) or p53/TP53. In monocytes by the Bacillus Calmette-Guerin (BCG). Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 16p13.13
Cellular Component: cytosol; Golgi apparatus; internal side of plasma membrane; intracellular membrane-bound organelle; lysosomal membrane; nucleoplasm; plasma membrane
Molecular Function: protein binding; signal transducer activity; WW domain binding; zinc ion binding
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter
Disease: Charcot-marie-tooth Disease, Demyelinating, Type 1c
Reference #:  Q99732 (UniProtKB)
Alt. Names/Synonyms: FLJ38636; lipopolysaccharide-induced TNF factor; lipopolysaccharide-induced TNF-alpha factor; Lipopolysaccharide-induced tumor necrosis factor-alpha factor; LITAF; LPS-induced TNF-alpha factor; MGC116698; MGC116700; MGC116701; MGC125274; MGC125275; MGC125276; p53-induced gene 7 protein; PIG7; SIMPLE; Small integral membrane protein of lysosome/late endosome; TP53I7; tumor protein p53 inducible protein 7
Gene Symbols: LITAF
Molecular weight: 17,107 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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