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Protein Page:
ROR2 (human)

Overview
ROR2 a receptor tyrosine kinase of the ROR family. May be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ror family; TK group
Chromosomal Location of Human Ortholog: 9q22
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding; Wnt-protein binding
Biological Process: multicellular organismal development; negative regulation of cell proliferation; positive regulation of cell migration; signal transduction; Wnt receptor signaling pathway, planar cell polarity pathway
Disease: Brachydactyly, Type B1; Robinow Syndrome, Autosomal Recessive
Reference #:  Q01974 (UniProtKB)
Alt. Names/Synonyms: BDB; BDB1; MGC163394; neurotrophic tyrosine kinase receptor-related 2; Neurotrophic tyrosine kinase, receptor-related 2; NTRKR2; receptor tyrosine kinase-like orphan receptor 2; ROR2; Tyrosine-protein kinase transmembrane receptor ROR2
Gene Symbols: ROR2
Molecular weight: 104,757 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ROR2

Protein Structure Not Found.
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