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Protein Page:
BMF (human)

Overview
BMF May play a role in apoptosis. Isoform 1 seems to be the main initiator. Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2. Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. Belongs to the Bcl-2 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cytoskeletal
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: acrosome; cytosol; mitochondrial outer membrane; myosin complex; plasma membrane
Molecular Function: protein binding
Biological Process: anoikis; apoptosis; positive regulation of protein homooligomerization; programmed cell death
Reference #:  Q96LC9 (UniProtKB)
Alt. Names/Synonyms: Bcl-2-modifying factor; Bcl2 modifying factor; BMF; FLJ00065
Gene Symbols: BMF
Molecular weight: 20,508 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BMF

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: S77‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
3 0 S74‑p DKATQTLsPAsPSQG
1 0 S77‑p TQTLsPAsPSQGVML
0 1 S109‑p YRLPLPAsFPAVLPI
0 2 L114 PAsFPAVLPIGEQPP
  mouse

 
S74‑p DKATQTLsPASPSQG
S77 TQTLsPASPSQGVML
S109 YRLPLPASFPAGsPL
S114‑p PASFPAGsPLGEQPP
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