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Protein Page:
P130Cas (human)

P130Cas a docking protein containing multiple protein-protein interaction domains. Plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. The amino-terminal SH3 domain regulates its interaction with focal adhesion kinase (FAK) and the FAK-related kinase PYK2 and also with tyrosine phosphatases PTP-1B and PTP-PEST. Overexpression confers antiestrogen resistance on breast cancer cells. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q23.1
Cellular Component: cytoplasm; cytosol; focal adhesion; nucleolus; plasma membrane; ruffle
Molecular Function: protein binding; protein kinase binding
Biological Process: actin filament organization; antigen receptor-mediated signaling pathway; B cell receptor signaling pathway; cell migration; cell proliferation; epidermal growth factor receptor signaling pathway; G-protein coupled receptor protein signaling pathway; hepatocyte growth factor receptor signaling pathway; insulin receptor signaling pathway; integrin-mediated signaling pathway; nerve growth factor receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; regulation of apoptosis; regulation of cell growth; vascular endothelial growth factor receptor signaling pathway
Reference #:  P56945 (UniProtKB)
Alt. Names/Synonyms: BCAR1; breast cancer anti-estrogen resistance 1; Breast cancer anti-estrogen resistance protein 1; CAS; Cas scaffolding protein family member 1; CAS1; CASS1; CRK-associated substrate; Crk-associated substrate p130Cas; CRKAS; FLJ12176; FLJ45059; p130cas
Gene Symbols: BCAR1
Molecular weight: 93,372 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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