Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
ACC1 (human)

ACC1 a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC; EC; Ligase; Lipid Metabolism - fatty acid biosynthesis
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: actin cytoskeleton; cytoplasm; cytosol; nucleolus
Molecular Function: acetyl-CoA carboxylase activity; protein binding
Biological Process: acetyl-CoA metabolic process; biotin metabolic process; carnitine shuttle; fatty acid biosynthetic process; positive regulation of cellular metabolic process; protein homotetramerization
Disease: Acetyl-coa Carboxylase Deficiency
Reference #:  Q13085 (UniProtKB)
Alt. Names/Synonyms: ACAC; ACACA; ACC; ACC-alpha; ACC1; ACCA; Acetyl-CoA carboxylase 1; acetyl-CoA carboxylase-alpha; acetyl-Coenzyme A carboxylase alpha; Biotin carboxylase
Gene Symbols: ACACA
Molecular weight: 265,554 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein