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Protein Page:
Bcl-6 (human)

Overview
Bcl-6 a zinc finger transcription factor and contains an N-terminal BTB/POZ domain. A sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. Mediates transcriptional repression and interacts with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The gene is frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 3q27
Cellular Component: nucleoplasm; nucleus; replication fork
Molecular Function: chromatin binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: myeloid cell differentiation; negative regulation of cell growth; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; protein import into nucleus, translocation; regulation of apoptosis; regulation of cell proliferation; regulation of inflammatory response; regulation of neurogenesis; response to DNA damage stimulus; T-helper 2 type immune response
Reference #:  P41182 (UniProtKB)
Alt. Names/Synonyms: B-cell CLL/lymphoma 6; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; BCL5; BCL6; BCL6A; cys-his2 zinc finger transcription factor; LAZ3; lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; ZBTB27; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51; zinc finger transcription factor BCL6S; ZNF51
Gene Symbols: BCL6
Molecular weight: 78,846 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Bcl-6

Protein Structure Not Found.
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