a zinc finger transcription factor and contains an N-terminal BTB/POZ domain. A sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. Mediates transcriptional repression and interacts with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The gene is frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Oncoprotein; C2H2-type zinc finger protein
Molecular Function: chromatin binding; chromatin DNA binding; metal ion binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: actin cytoskeleton organization and biogenesis; B cell differentiation; cell morphogenesis; erythrocyte development; germinal center formation; inflammatory response; myeloid cell differentiation; negative regulation of B cell apoptosis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cell-matrix adhesion; negative regulation of isotype switching to IgE isotypes; negative regulation of mast cell cytokine production; negative regulation of Notch signaling pathway; negative regulation of Rho protein signal transduction; negative regulation of T-helper 2 cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of B cell proliferation; positive regulation of cell motility; positive regulation of histone deacetylation; positive regulation of neuron differentiation; protein import into nucleus, translocation; regulation of apoptosis; regulation of cell proliferation; regulation of germinal center formation; regulation of GTPase activity; regulation of immune response; regulation of inflammatory response; regulation of memory T cell differentiation; regulation of neurogenesis; response to DNA damage stimulus; Rho protein signal transduction; spermatogenesis; T-helper 2 type immune response; transcription, DNA-dependent
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.