a zinc finger transcription factor and contains an N-terminal BTB/POZ domain. A sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. Mediates transcriptional repression and interacts with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The gene is frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Oncoprotein; C2H2-type zinc finger protein
Molecular Function: chromatin binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: myeloid cell differentiation; negative regulation of cell growth; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; protein import into nucleus, translocation; regulation of apoptosis; regulation of cell proliferation; regulation of inflammatory response; regulation of neurogenesis; response to DNA damage stimulus; T-helper 2 type immune response
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.