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Protein Page:
DAB1 (human)

Overview
DAB1 an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1p32-p31
Cellular Component: intracellular membrane-bound organelle; microtubule organizing center; nucleolus
Molecular Function: protein binding
Reference #:  O75553 (UniProtKB)
Alt. Names/Synonyms: DAB1; Disabled homolog 1; disabled homolog 1 (Drosophila)
Gene Symbols: DAB1
Molecular weight: 63,775 Da
Basal Isoelectric point: 4.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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DAB1

Protein Structure Not Found.
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