a member of the RAD51 protein family. Involved in the homologous recombination and repair of DNA. Interacts with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. Interacts with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both its intracellular localization and DNA-binding ability. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Defects in RAD51 are associated with breast cancer. Two alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Molecular Function: ATP binding; chromatin binding; double-stranded DNA binding; endodeoxyribonuclease activity; four-way junction DNA binding; identical protein binding; protein binding; protein C-terminus binding; recombinase activity; single-stranded DNA binding; single-stranded DNA-dependent ATPase activity
Biological Process: DNA recombinase assembly; DNA recombination; DNA repair; DNA synthesis during DNA repair; DNA unwinding during replication; double-strand break repair via homologous recombination; meiosis; meiotic recombination; mitotic recombination; positive regulation of DNA ligation; protein homooligomerization; regulation of protein amino acid phosphorylation; replication fork processing; response to DNA damage stimulus; response to drug; response to toxin; response to X-ray; strand displacement; strand invasion; telomere maintenance via recombination
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.