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Protein Page:
G-alpha 11 (human)

Overview
G-alpha 11 a guanine nucleotide-binding protein of the G-alpha family. Acts as an activator of phospholipase C. Involved in signaling of gonadotropin-releasing hormone receptor, negatively regulating cell growth. Down-regulation may be involved in human breast cancers. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytoplasm; lysosomal membrane; photoreceptor outer segment; plasma membrane
Molecular Function: GTPase activity; type 2A serotonin receptor binding
Biological Process: acetylcholine receptor signaling, muscarinic pathway; dopamine receptor, phospholipase C activating pathway; entrainment of circadian clock; phototransduction, visible light; platelet activation; regulation of action potential; signal transduction
Disease: Hypocalciuric Hypercalcemia, Familial, Type Ii
Reference #:  P29992 (UniProtKB)
Alt. Names/Synonyms: G alpha-11; G-protein subunit alpha-11; GA11; GNA-11; GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding protein G(y) subunit alpha; Guanine nucleotide-binding protein subunit alpha-11; guanine nucleotide-binding protein, Gq class, GNA11
Gene Symbols: GNA11
Molecular weight: 42,123 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Phospholipase Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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G-alpha 11

Protein Structure Not Found.


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