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Protein Page:
FRS2 (human)

FRS2 an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: endosome; integral to plasma membrane; intercellular junction; membrane; plasma membrane
Molecular Function: 1-phosphatidylinositol-3-kinase activity; fibroblast growth factor receptor binding; neurotrophin TRKA receptor binding; phosphatase activator activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; Ras guanyl-nucleotide exchange factor activity; transmembrane receptor protein tyrosine kinase adaptor protein activity
Biological Process: activation of MAPKK activity; fibroblast growth factor receptor signaling pathway; G-protein coupled receptor protein signaling pathway; MAPKKK cascade; phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade; transmembrane receptor protein tyrosine phosphatase signaling pathway
Reference #:  Q8WU20 (UniProtKB)
Alt. Names/Synonyms: FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; FRS2; FRS2A; FRS2alpha; SNT; SNT-1; SNT1; Suc1-associated neurotrophic factor target 1
Gene Symbols: FRS2
Molecular weight: 57,029 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
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