a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2. Note: This description may include information from UniProtKB.
Molecular Function: acetyltransferase activity; androgen receptor binding; beta-catenin binding; bHLH transcription factor binding; chromatin binding; chromatin DNA binding; damaged DNA binding; DNA binding; glucocorticoid receptor binding; histone acetyltransferase activity; lysine N-acetyltransferase activity; mitogen-activated protein kinase binding; NF-kappaB binding; nuclear hormone receptor binding; p53 binding; peptide N-acetyltransferase activity; peroxisome proliferator activated receptor binding; protein binding; protein C-terminus binding; protein complex binding; SMAD binding; transcription activator binding; transcription coactivator activity; transcription factor binding; transferase activity, transferring acyl groups; zinc ion binding
Biological Process: apoptosis; B cell differentiation; circadian rhythm; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; fat cell differentiation; gut development; heart development; internal peptidyl-lysine acetylation; internal protein amino acid acetylation; liver development; lung development; memory; N-terminal peptidyl-lysine acetylation; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; nervous system development; Notch signaling pathway; organ morphogenesis; platelet formation; positive regulation of axon extension; positive regulation of cell size; positive regulation of collagen biosynthetic process; positive regulation of DNA binding; positive regulation of gene expression, epigenetic; positive regulation of histone acetylation; positive regulation of interferon type I production; positive regulation of muscle atrophy; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; positive regulation of protein secretion; positive regulation of proteolysis; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription of target genes involved in unfolded protein response; positive regulation of translation; protein amino acid acetylation; protein kinase B signaling cascade; protein stabilization; protein-DNA complex assembly; regulation of angiotensin metabolic process; regulation of autophagy; regulation of cell cycle; regulation of transcription, DNA-dependent; response to calcium ion; response to cobalt ion; response to estrogen stimulus; response to ethanol; response to hypoxia; skeletal muscle development; somitogenesis; stimulatory C-type lectin receptor signaling pathway; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair; viral reproduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.