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Protein Page:
p300 (human)

p300 a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: acetyltransferase activity; androgen receptor binding; beta-catenin binding; chromatin binding; damaged DNA binding; DNA binding; histone acetyltransferase activity; lysine N-acetyltransferase activity; nuclear hormone receptor binding; peptide N-acetyltransferase activity; protein binding; protein C-terminus binding; transcription activator binding; transcription coactivator activity; transcription factor binding; transferase activity, transferring acyl groups
Biological Process: apoptosis; circadian rhythm; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; fat cell differentiation; internal peptidyl-lysine acetylation; internal protein amino acid acetylation; N-terminal peptidyl-lysine acetylation; negative regulation of transcription from RNA polymerase II promoter; nervous system development; Notch signaling pathway; positive regulation of gene expression, epigenetic; positive regulation of interferon type I production; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription of target genes involved in unfolded protein response; protein amino acid acetylation; protein stabilization; regulation of autophagy; regulation of cell cycle; regulation of transcription, DNA-dependent; response to estrogen stimulus; response to hypoxia; stimulatory C-type lectin receptor signaling pathway; transcription-coupled nucleotide-excision repair
Disease: Colorectal Cancer; Rubinstein-taybi Syndrome 1; Rubinstein-taybi Syndrome 2
Reference #:  Q09472 (UniProtKB)
Alt. Names/Synonyms: E1A binding protein p300; E1A-associated protein p300; E1A-binding protein, 300kD; EP300; Histone acetyltransferase p300; KAT3B; P300; p300 HAT
Gene Symbols: EP300
Molecular weight: 264,161 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  G2/M DNA Damage Checkpoint  |  NF-kB Signaling  |  Protein Acetylation
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