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Protein Page:
Merlin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Merlin a moesin-ezrin-radizin-like protein. Interacts with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. Expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations are associated with neurofibromatosis type II. Two predominant isoforms and eight minor isoforms are produced by alternatively spliced transcripts. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: cytoplasm; cytoskeleton; early endosome; membrane; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: protein binding
Biological Process: actin cytoskeleton organization and biogenesis; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell-cell adhesion; negative regulation of cell-matrix adhesion; negative regulation of DNA replication; negative regulation of JAK-STAT cascade; negative regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of stress fiber formation; Schwann cell proliferation
Disease: Meningioma, Familial, Susceptibility To; Neurofibromatosis, Type Ii; Schwannomatosis 1
Reference #:  P35240 (UniProtKB)
Alt. Names/Synonyms: ACN; BANF; MERL; Merlin; moesin-ezrin-radixin like; Moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2; neurofibromin 2 (bilateral acoustic neuroma); neurofibromin 2 (merlin); Neurofibromin-2; NF2; SCH; Schwannomerlin; Schwannomin
Gene Symbols: NF2
Molecular weight: 69,690 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Merlin

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
cell adhesion, altered: S518‑p
cell cycle regulation: S518‑p
cell growth, altered: S518‑p
cell growth, induced: S518‑p
cell motility, altered: S10‑p, S518‑p
cytoskeletal reorganization: S10‑p, S518‑p
transcription, altered: S518‑p
activity, inhibited: S518‑p
intracellular localization: S518‑p
molecular association, regulation: S518‑p
phosphorylation: S518‑p
protein conformation: S518‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 7 S10‑p GAIASRMsFSsLkRK
0 14 S13‑p ASRMsFSsLkRKQPK
0 1 K15‑sm RMsFSsLkRKQPKTF
1 0 K76‑sm KDTVAWLkMDKkVLD
0 4 K80‑ub AWLkMDKkVLDHDVS
0 1 K159‑ub DYDPSVHkRGFLAQE
0 1 K171‑ub AQEELLPkRVINLYQ
3 0 T230‑p AIRNKKGtELLLGVD
0 1 K269‑ub RNISYSDkEFTIKPL
0 1 K279‑ac TIKPLDKkIDVFKFN
3 3 S315‑p MRRRKADsLEVQQMK
0 2 R351‑m2 QMREEAErTrDELER
0 2 R353‑m2 REEAErTrDELERRL
0 1 K364 ERRLLQMKEEATMAN
0 1 K387‑ub TADLLAEkAQITEEE
0 1 T391 LAEkAQITEEEAkLL
0 8 K396‑ub QITEEEAkLLAQkAA
0 1 K401‑ub EAkLLAQkAAEAEQE
0 1 T415‑p EMQRIKAtAIRtEEE
0 1 T419‑p IKAtAIRtEEEKRLM
0 1 K439 EAEVLALKMAEESER
0 1 T477‑p QKLLEIAtKPTYPPM
24 33 S518‑p DTDMKRLsMEIEKEK
0 1 K543 QEQLNELKTEIEALk
0 1 K550‑sm KTEIEALkLKERETA
0 1 R568 LHNENSDRGGSSKHN
0 9 T581‑p HNTIKKLtLQSAKsR
0 3 S587‑p LtLQSAKsRVAFFEE
9163 : Phospho-Merlin (Ser518) Antibody
13281 : Phospho-Merlin (Ser518) (D5A4I) Rabbit mAb
  mouse

 
S10‑p GAIASRMsFSsLKRK
S13‑p ASRMsFSsLKRKQPK
K15 RMsFSsLKRKQPKTF
K76 KDTVAWLKMDKkVLD
K80‑ub AWLKMDKkVLDHDVS
K159 DYDPSVHKRGFLAQE
K171 AQEELLPKRVINLYQ
T230 TIRNKKGTELLLGVD
K269 RNISYSDKEFTIKPL
K279 TIKPLDKKIDVFKFN
S315‑p MRRRKADsLEVQQMK
R351 QMREEAERTRDELER
R353 REEAERTRDELERRL
K364‑ub ERRLLQMkEEATMAN
K387 TADLLAEKAQItEEE
T391‑p LAEKAQItEEEAkLL
K396‑ub QItEEEAkLLAQKAA
K401 EAkLLAQKAAEAEQE
T415 EMQRIKATAIRTEEE
T419 IKATAIRTEEEKRLM
K439‑ac EAEVLALkMAEESER
T477 QKLLEIATKPTYPPM
S518‑p DTDMKRLsMEIEKEK
K543‑ac QEQLNELkTEIEALK
K550 kTEIEALKLKERETA
R568‑m1 LHSESSDrGGPSSKH
T582‑p HNTIKKLtLQSAKSR
S588 LtLQSAKSRVAFFEE
9163 : Phospho-Merlin (Ser518) Antibody
13281 : Phospho-Merlin (Ser518) (D5A4I) Rabbit mAb
  rat

 
S6 __IASRMSFSsLKRK
S9‑p ASRMSFSsLKRKQPK
K11 RMSFSsLKRKQPKTF
K72 KDTVAWLKMDKKVLD
K76 AWLKMDKKVLDHDVS
K155 DYDPSVHKRGFLAQE
K167 AQEELLPKRVINLYQ
T226 TIRNKKGTELLLGVD
K265 RNISYSDKEFTIKPL
K275 TIKPLDKKIDVFKFN
S311 MRRRKADSLEVQQMK
R347 QMREEAERSRDEPER
R349 REEAERSRDEPERRV
K360 ERRVLHMKEEATMAN
K383 TADLLAEKAQITEEE
T387 LAEKAQITEEEAKLL
K392 QITEEEAKLLAQKAA
K397 EAKLLAQKAAEAEQE
T411 EMQRIKATAIRTEEE
T415 IKATAIRTEEEKRLM
K435 EAEVLALKMAEESER
T473 QKLLEIATKPTYPPM
S514‑p DTDMKRLsMEIEKEK
K539 QEQLNELKTEIEALK
K546 KTEIEALKLKERETA
S564 LHSEHSDSGTSSKHN
Q577 HNTIKKPQAQGRRPI
- gap
9163 : Phospho-Merlin (Ser518) Antibody
13281 : Phospho-Merlin (Ser518) (D5A4I) Rabbit mAb
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