a moesin-ezrin-radizin-like protein. Interacts with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. Expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations are associated with neurofibromatosis type II. Two predominant isoforms and eight minor isoforms are produced by alternatively spliced transcripts. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Motility/polarity/chemotaxis; Cytoskeletal
Cellular Component: cytoplasm; cytoskeleton; early endosome; membrane; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: protein binding
Biological Process: actin cytoskeleton organization and biogenesis; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell-cell adhesion; negative regulation of cell-matrix adhesion; negative regulation of DNA replication; negative regulation of JAK-STAT cascade; negative regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of stress fiber formation; Schwann cell proliferation
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.