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Protein Page:
GAB2 (human)

Overview
GAB2 an adaptor protein of the GRB2-associated binding protein family. Plays important roles in regulating the growth, differentiation, and function of many hematopoietic cell types. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11q14.1
Cellular Component: cytoplasm; cytosol; plasma membrane
Molecular Function: phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; transmembrane receptor protein tyrosine kinase adaptor protein activity
Biological Process: osteoclast differentiation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of mast cell degranulation
Reference #:  Q9UQC2 (UniProtKB)
Alt. Names/Synonyms: GAB2; GRB2-associated binder 2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; Growth factor receptor bound protein 2-associated protein 2; KIAA0571; pp100
Gene Symbols: GAB2
Molecular weight: 74,458 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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GAB2

Protein Structure Not Found.
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