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Protein Page:
EIF4B (human)

Overview
EIF4B eukaryotic translation initiation factor 4B. Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation; Translation initiation
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cytosol; eukaryotic translation initiation factor 4F complex; polysome
Molecular Function: helicase activity; protein binding; ribosomal small subunit binding; RNA binding; RNA strand annealing activity; RNA strand-exchange activity
Biological Process: formation of translation preinitiation complex; poly(A) tail shortening; regulation of translational initiation; translational initiation
Reference #:  P23588 (UniProtKB)
Alt. Names/Synonyms: eIF-4B; EIF4B; Eukaryotic translation initiation factor 4B; IF4B; PRO1843
Gene Symbols: EIF4B
Molecular weight: 69,151 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Translation: eIF4E and p70S6K  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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EIF4B

Protein Structure Not Found.
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